Postdoctoral Research Scientist position available

A position is available for a Postdoctoral Fellow at the Prostate Cancer Lab to join an ongoing project in epigenetic modulation of androgen receptor activity as well as to develop new projects in the field of therapeutic resistance in prostate cancer.

Candidates must send a complete CV, cover letter and three references to aaytes@idibell.cat. Candidates must demonstrate an excellent track of early achievements (independent funding during her/his PhD and peer reviewed publications, among others). For more information about the positions please contact me at aaytes@idibell.cat

The Prostate Cancer Laboratory is a member of the Program Against Cancer Therapeutic Resistance (ProCure) at the Catalan Institute of Oncology, one of the founding institutions at the Bellvitge Institute for Biomedical Research (www.idibell.cat). The laboratory utilizes Genetically-Engineered Mouse (GEM) models of prostate cancer to elucidate mechanisms of progression to advanced, metastatic castration resistant prostate cancer. We also incorporate Cancer Systems Biology approaches to conduct cross-species studies in mouse and human specimens to design experimental therapeutics and preclinical investigations.

 

References.

Mitrofanova A*, Aytes A*, Zou M, Shen MM, Abate-Shen C, Califano A. Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models. Cell Rep. 2015 Sep 29;12(12):2060-71. *Equally contributed

Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE. DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis. Cancer Cell. 2015 Jul 13;28(1):97-113

Aytes A, Mitrofanova A, Lefebvre C, Alvarez MJ, Castillo-Martin M, Zheng T,Eastham JA, Gopalan A, Pienta KJ, Shen MM, Califano A, Abate-Shen C. Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014 May 12;25(5):638-51

Irshad S, Bansal M, Castillo-Martin M, Zheng T, Aytes A, Wenske S, Le Magnen  C, Guarnieri P, Sumazin P, Benson MC, Shen MM, Califano A, Abate-Shen C. A molecular signature predictive of indolent prostate cancer. Sci Transl Med. 2013 Sep 11;5(202):202ra122

Aytes A, Mitrofanova A, Kinkade CW, Lefebvre C, Lei M, Phelan V, LeKaye HC, Koutcher JA, Cardiff RD, Califano A, Shen MM, Abate-Shen C. ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3506-15