Serum triglyceride concentration and risk of PCa: a prospective multicenter study

18 October 2010

October 2010- S. Salem and colleagues of Tehran, Iran, won the 3rd Prize for Best Abstract from Richard Wolf during the 6th South Eastern European Meeting (SEEM) held in Istanbul, Turkey. The abstract of their study appears below:

Serum lipid concentration as a part of the metabolic syndrome is supposed to be linked to prostate cancer risk. However, few epidemiological studies have assessed the relation between serum triglyceride level and risk of prostate cancer (PCa). This study sought to further evaluate the probable association between serum triglyceride level and prostate cancer risk.

Using data from a prospective hospital-based multicenter case-control study, serum triglyceride concentration as well as thorough demographic and medical characteristics were determined in 194 cases with the newly diagnosed, clinicopathologically confirmed PCa and 317 controls, without any malignant disease, admitted to the same network of hospitals.

Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were obtained after adjustment for major potential confounders, including age, body mass index, smoking, alcohol, education, occupation and family history of PCa.

The results showed that the mean (+/-SD) serum triglyceride level in case and control groups were 141.24+/-74.39 mg/dl and 143.38+/-71.51 mg/dl, respectively; the difference was not statistically significant (p=0.76). Comparing the highest with the lowest tertile, serum triglyceride concentration was not associated with the increased risk of prostate cancer (OR: 1.24, 95% CI: 0.08-3.12; P=0.18).

“Our findings do not support the hypothesis that serum triglyceride level may be involved in the pathogenesis of prostate cancer,” the researchers concluded.

Source: S. Salem, et al., “Serum triglyceride concentration and risk of prostate cancer: A prospective multicenter study,” 3rd Prize Best Abstract Richard Wolf, Poster Session, 6th South Eastern European Meeting (SEEM), 1-2 October 2010, Istanbul, Turkey.

S. Salem (right) won the 3rd Prize for Best Abstract from Richard Wolf. Professors Michael Marberger (left) and Tarik Esen (middle) handed out the award in Istanbul, Turkey

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