10. CONFLICT OF INTEREST

All members of the EAU - EANM - ESTRO - ESUR - ISUP – SIOG Prostate Cancer Guidelines Working Group have provided disclosure statements of all relationships that they have that might be perceived as a potential source of a conflict of interest. This information is publicly accessible through the European Association of Urology website: https://uroweb.org/guidelines/prostate-cancer/panel.

This guidelines document was developed with the financial support of the European Association of Urology. No external sources of funding and support have been involved. The EAU is a non-profit organisation, and funding is limited to administrative assistance and travel and meeting expenses. No honoraria or other reimbursements have been provided.

Disclosures: The EAU Guidelines Office certifies that all conflicts of interest, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/ affiliation, grants or funding, consultancies, honoraria, stock ownership or options, expert testimony, royalties, or patents filed, received, or pending), are the following:

P. Cornford reported receiving company honoraria or consultation fees from Accord Healthcare, AstraZeneca and Bayer UK; receiving company speaker honoraria fees from Astellas Pharma a/s Danish Sales, AstraZeneca, Bayer UK, Ipsen Biopharm and Janssen Cilag; and serving on the board of trustees of Prostate Cancer Research.

D. Tilki reported receiving company honoraria or consultation fees from A3P Biomedical AB, Astellas Pharma, Bayer Vital, Novartis Pharma and Veracyte.

R.C.N. van den Bergh reported receiving company honoraria or consultation fees from Astellas Pharma International, Ipsen Farmaceutica and Johnson & Johnson Innovative Medicine; participation in a company sponsored speaker's bureau for Amgen; receiving fellowship or travel grants from Bayer; and receiving grants or research support from Astellas and Johnson & Johnson Innovative Medicine.

D. Eberli reported receiving company speaker honoraria fees from Astellas Pharma, Bayer (Schweiz), EDAP Germany and Janssen Cilag; serving as a company consultant to Astellas Pharma, Bayer (Schweiz), EDAP Germany and Iaculis; receiving grants or research support from Astellas Pharma, Bayer (Schweiz) and EDAP TMS; receiving fellowship or travel grants from Bayer (Schweiz); being a stock shareholder in MUVON Therapeutics and Ontrack Biomedical; serving as a director of the Department of Urology at University Hospital Zurich; holding an appointment as a Professor at University of Zurich; and being the owner of three patents.

V. Fonteyne reporting participation in the THUNDER (NCT06282588) and SAVE trials; received honoraria for lectures from Johnson & Johnson, Astellas, Bristol Myers Squibb and Issecam; travel support from Johnson & Johnson; and participation on advisory boards from Astellas.

M. De Santis reported receiving company honoraria or consultation fees from Amgen, Astellas Pharma EMEA, De Santis, AAA, AbVie, Amgen, Astellas, AstraZeneca, Basilea, Bayer, BMS, EISAI, Ferring, Gilead, Immunomedics, Ipsen, Janssen, MSD, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi, SeaGen and Thermosome; and participation in clinical trials by Amgen, Astellas, AstraZeneca, Bayer, BMS, EISAI, Ferring, Ipsen, Janssen, MSD, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi, Amgen, Astellas, AstraZeneca, Bayer, BMS, EISAI, Ferring, Ipsen, Janssen, MSD, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi and SeaGen.

G. Gandaglia reported receiving company speaker honorarium from Accord Healthcare and Ipsen; honoraria or consultation fees from Bayer S.p.A. and Janssen Cilag S.p.A; fellowship, travel grants from Bayer S.p.A. and Ipsen S.p.A; being a company consultant for Telix; and receiving grants/research supports from AIRC - Fondazione AIRC per la ricerca sul cancro.

S. Gillessen reported receiving company honoraria or consultation fees from Amgen, Astellas Pharma, Boehringer Ingelheim Pharma, Daiichi Sankyo Schweiz, Ipsen Innovation, Novartis Pharma, PeerVoice, University of Applied Sciences and Arts of Southern Switzerland, UroPratica Group, EPG Health, Macrogenics, Avalere Health, InnoMedica Schweiz and Silvio Grasso Consulting; receiving company speaker honoraria fees from ASCO, ESMO, Orikata, PlayToKnow, Intellisphere, SGMO and AdMeTech Foundation; receiving fellowship or travel grants from Bayer (Schweiz), Johnson & Johnson Innovative Medicine, Intellisphere and Gilead; serving as a company consultant to Bayer (Schweiz), BMS, Merck - Pfizer Alliance, MSD, Pfizer and LinkinVax; participation in a company sponsored speaker's bureau for SAKK; being the owner of one patent; and attending a senior executive meeting at AstraZeneca.

A.M. Henry reported receiving grants or research support from the University of Leeds; and participation in clinical trials for Cancer Research UK.

J. Oldenburg reported receiving company honoraria or consultation fees from Astellas Pharma Norway, BMS, Janssen Cilag, MSD (Norge), Pfizer and Roche Accord; and receiving company speaker honoraria fees from Astellas Pharma Norway and Janssen Cilag.

D.E. Oprea-Lager reported receiving company honoraria or consultation fees from Novartis, Bayer, Curium, Ipsen, Astellas, Janssen and Telix.

I. van Oort reported receiving grants/research supports from Amgen, Astellas, Bayer B.V. and Novartis Pharma; receiving honoraria or consultation fees from Bayer B.V. and Novartis Pharma; and receiving company speaker honorarium from Recordati B.V.

M. Roberts reported receiving company honoraria or consultation fees from Astellas Pharma Australia, AstraZeneca, Janssen and Cook Medical Australia; receiving fellowship or travel grants from Bayer Australia; receiving grants or research support from ANZUP Cancer Trials Group; serving as a company consultant to BXTAccelyon Australia; and participation in clinical trials by Janssen and AdvanCell Isotopes.

O. Rouvière reported receiving fellowship or travel grants from Philips France; and being the owner of one international patent.

J. Stranne reported being the chair of the Swedish national guidelines committee.

T. Wiegel reported receiving company speaker honoraria fees from Bayer Vital GmbH, Ipsen Pharma GmbH, Janssen, Johnson & Johnson Innovative Medicine, Recordati, Takeda Pharma Vertrieb GmbH & Co. KG; serving as a company consultant to Janssen; serving as a member of the steering committee of the German association of scientific medical societies S3 prostate guidelines.

P. Chiu reported receiving speaker honoraria fees for a lecture.

G. Gandaglia reported receiving company speaker honoraria fees from Accord Healthcare and Ipsen; receiving company honoraria or consultation fees from Bayer and Janssen Cilag; receiving fellowship or travel grants from Bayer and Ipsen; serving as a company consultant to Telix; and receiving grants or research support from AIRC.

E. Linares Espinós reported receiving company honoraria or consultation fees from Bayer, Astellas, Casen Recordati, MSD Spain and Pfizer Spain; receiving company speaker honoraria fees from Johnson & Johnson, Ipsen Pharma, Bayer, and Astellas; serving as a company consultant to Ipsen Pharma, Bayer and Johnson & Johnson; participation in clinical trials by Janssen Cilag; and receiving grants or research support from Astellas.

A. Sachdeva reported receiving company speaker honoraria fees from Ipsen, Janssen Cilag; receiving company honoraria or consultation fees from Ipsen and Veracyte; receiving fellowship or travel grants from the Prostate Cancer Foundation; and participation in the STAMPEDE trial.

G.J.L.H. van Leenders Geert J.L.H. van Leenders is President Elect of the International Society of Urological Pathology (ISUP) and co-chair of the European Society of Pathology (ESP) Uropathology working group.

I.G. Schoots, A. Epure, E. Briers, B. Madsen, A. Farolfi and N. Grivas have nothing to declare.