For the 2025 UTUC Guidelines, new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the Guidelines. This resulted in the inclusion of 17 updated studies across the Guidelines. Key changes include:
- Significant changes to the recommendations for the diagnosis of UTUC in section 5.7.
- Complete revision of Chapter 6 Risk stratification.
- Complete revision of section 7.1.2 Ureteroscopy.
- The addition of two new recommendations to section 7.1.7 related to kidney-sparing management of localised low-risk UTUC.
- Complete revision of section 7.2.1.1 Surgical approach for radical nephroureterectomy.
- The addition of two new recommendations to section 7.2.5 related to management of high-risk non-metastatic UTUC.
- Review and adaption of the section 8.1 recommendations for the follow-up of UTUC.
- Addition of a new chapter addressing quality indicators for the management of UTUC, chapter 9.