For the 2024 UTUC Guidelines, new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the Guidelines. Key changes include the addition of:
- New text and guidelines updates in section 3.2.2 on the genetic risk factors and the implications of identifying lynch syndrome’s related UTUCs, and in section 3.4 on the molecular background of UTUCs;
- new text updates in section 6.1.2.2 on tumour location, multifocality, size and hydronephrosis;
- updates in section 6.2 on the risk stratification for clinical decision making, both in text and evidence;
- key updates to the text, evidence and guidelines in section 7.3.2 on the management of distant metastases.