Testicular Cancer

Full Text Guidelines Summary of Changes Scientific Publications & Appendices Pocket Guidelines Archive Panel

ISBN 978-94-92671-13-4

M.P. Laguna (Chair), P. Albers, F. Algaba, C. Bokemeyer, J.L. Boormans, S. Fischer, K. Fizazi, H. Gremmels (Patient advocate), R. Leão, D. Nicol, N. Nicolai, J. Oldenburg, T. Tandstad
Guidelines Associates: J. Mayor de Castro, C.D. Fankhauser, F. Janisch, , T. Muilwijk
Consultant radiologist: Y. Jain

1.INTRODUCTION

1.1.Aim and objectives

The aim of these guidelines is to present the current evidence for the diagnosis and treatment of patients with cancer of the testis. Testicular cancer (TC) represents 5% of urological tumours affecting mostly younger males. This document addresses post-pubertal testicular germ-cell tumours (TGCTs) in the male including spermatocytic tumour and sex cord/gonadal stromal tumours.

It must be emphasised that clinical guidelines present the best evidence available to the experts but following guideline recommendations will not necessarily result in the best outcome. Guidelines can never replace clinical expertise when making treatment decisions for individual patients, but rather help to focus decisions which should also take personal values and preferences/individual circumstances of patients into account. Guidelines are not mandates and do not purport to be a legal standard of care.

1.2.Panel composition

The European Association of Urology (EAU) Guidelines Panel on TC consists of a multidisciplinary group of clinicians including, urologists, medical oncologists, a radiation-oncologist and a pathologist. When necessary, consultants from other specialties provide input. Members of this Panel have been selected, based on their expertise, to represent the professionals treating patients with TC. All experts involved in the production of this document have submitted potential conflict of interest statements which can be viewed on the EAU website: http://www.uroweb.org/guideline/testicular-cancer/.

1.3.Available publications

A quick reference document (Pocket guidelines) is available, in print and as an app for iOS and Android devices. These are abridged versions which may require consultation together with the full text version. Several scientific publications are available, as are a number of translations of all versions of the EAU Testicular Cancer Guidelines. All documents are accessible through the EAU website: http://www.uroweb.org/guideline/testicularcancer/.

1.4.Publication history and summary of changes

1.4.1.Publication history

The EAU published the first guidelines on TC in 2001. Since 2008, the TC Guidelines contains a separate chapter on testicular stromal tumours. This document presents a limited update of the 2019 publication. Review papers have been published in the society’s scientific journal European Urology, the latest version dating to 2015 [1].

1.4.2.Summary of changes

For the 2021 Testicular Cancer Guidelines, new references have been added throughout the document. Key changes in this publication include:

  • The chapter on stromal tumours has been re-structured and revised under a new heading: “Rare adult testicular tumours”;
  • The chapter on epidemiology, aetiology and pathology has been revised;
  • Summaries of evidence have been added throughout the text;
  • Old citations have been refreshed and replaced with newer references;
  • A number of articles identified after the scope search cut-off date have been included as they contain important information pertaining to guidelines recommendations;
  • Supporting text and recommendations across the guideline have been rephrased and revised;
  • The recent re-validation of the 1997 International Germ Cell Cancer Collaborative Group (IGCCCG) prognostic risk-factor based system for metastatic testicular Germ cell tumours in patients treated with cisplatin-etoposide as first-line chemotherapy has been included in the text replacing the old version;
  • New recommendations and supporting text regarding VTE prophylaxis in males with metastatic germ cell tumours (GCTs) receiving chemotherapy have been added.
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