For the 2025 Non-neurogenic Female LUTS Guidelines new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the guidelines. Key changes include:
- A new summary of evidence (SOE) in section 3.71 for pad tests.
- New SOE and recommendations in section 4.1.4.1.2.1 for conservative management of OAB.
- Summarized text in section 4.1.4.1.3 and an additional SOE with regards to urinary containment.
- New SOE and recommendation in section 4.1.4.1.5.5 for behavioural and physical therapies.
- A new recommendation for anticholinergic drugs in section 4.1.4.2.1.4.
- A new section 4.1.4.2.6 on Saw palmetto extract.
- A new SOE for detrusor myomectomy in section 4.1.4.3.4.4.
- A new SOE for pelvic floor muscle training in section 4.2.4.1.3.7.
- A new SOE and recommendations for electromagnetic stimulation and electroacupuncture in section 4.2.4.1.6.
- A new recommendation in section 4.2.4.3.2.5.1 for mid-urethral slings and in section 4.2.4.3.2.6.1 for treatment of stress urinary incontinence.
- A new section 4.3.3.3.2 on Mirabegron as well as a new SOE.
- A new SOE in section 4.5.5.2.3.3 for surgical management of functional bladder out let obstruction.
- Extensive update on the pharmacological management of Nocturia, including new SOE in section 4.6.4.3.
- A new SOE and recommendation for detection of SUI in women with POP, in section 4.7.3.2.
- A new recommendation for the classification of urinary fistula in section 4.8.2.1