For the 2026 PUC Guidelines, new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the Guidelines. Key changes include:
- In Chapter 4, the 9th edition (2025) of the Tumour, Node, Metastasis (UICC/TNM) classification is incorporated.
- In Chapter 6, updates regarding prognostic factors.
- In Section 7.3.6, updated recommendations for multimodal treatment of advanced urethral carcinoma.