For the 2025 Sexual and Reproductive Health Guidelines new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the Guidelines. Key changes include:
- Significant changes to section 5.4.4 Cardiovascular system and sexual activity: the patient at risk. This section has been completely restructured and updated including figures 5.2 and 5.3.
- Two new recommendations in section 5.6.12 Summary of evidence and recommendations for treatment of ED.
- Modification of the recommendation for penile surgery for adult acquired buried penis in section 9.3.2.2.5.
- Addition of a new sections – section 11.3.5.4 Exome sequencing and 11.5.1.3 Probiotic treatment.
- Update of the recommendations in section 11.3.7.