For the 2026 Urolithiasis Guidelines new and relevant evidence was identified, collated and appraised through a structured assessment of the literature for all sections of the Guidelines. This resulted in the inclusion of 126 updated studies across the Guidelines. Key changes include:
- Revision of the summary of evidence and recommendations for the management of renal colic
- Revision of Section 3.4.3, Medical expulsive therapy.
- Revision of the information on antibiotic prophylaxis in Section 3.4.5, Extracorporeal shock wave lithotripsy
- Revision of the summary of evidence and recommendations for shockwave lithotripsy
- Revision of Section 3.4.6, Ureteroscopy (retrograde and antegrade)
- Revision of Section 3.4.7, Percutaneous nephrolithotomy
- Revision of the Section 3.4.8.b, Antithrombotic therapy and stone treatment
- Revision of Section 3.4.15.e, Endourological procedures Rigid/semi-rigid ureteroscopy
- Revision of Section 3.5, Radiation exposure and protection during endourology
- Revision of Section 4.6, Disorders and diseases related to calcium stones
- Updates to Table 3.2, Stone composition
- Updates to Table 3.11, Suggested strategy for antithrombotic therapy in stone removal
- Updates to Table 4.2, Laboratory values for urinary parameters in adults
- Updates to Table 4.3, Normal values for spot urine samples: creatinine ratios (solute/creatinine) in children
- Updates to Table 4.6, Pharmacological substances used for stone prevention - characteristics, specifics, and dosage
- Revised and updated references throughout the text.
A new recommendation was also added to section 3.4.5.a Summary of evidence and recommendations for shock wave lithotripsy