8. REFERENCES
1.World Health Organization. Palliative care. 2022.
https://www.who.int/health-topics/palliative-care
2.Paterson, C., et al. What are the unmet supportive care needs of men affected by penile cancer? A systematic review of the empirical evidence. Eur J Oncol Nurs, 2020. 48: 101805.
https://www.ncbi.nlm.nih.gov/pubmed/32947156
3.Guyatt, G.H., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ, 2008. 336: 924.
https://www.ncbi.nlm.nih.gov/pubmed/18436948
4.Guyatt, G.H., et al. What is “quality of evidence” and why is it important to clinicians? BMJ, 2008. 336: 995.
https://www.ncbi.nlm.nih.gov/pubmed/18456631
5.Phillips, B., et al. Oxford Centre for Evidence-based Medicine Levels of Evidence. Updated by Jeremy Howick March 2009.
https://www.cebm.net/wp-content/uploads/2014/06/CEBM-Levels-of-Evidence.pdf
6.Guyatt, G.H., et al. Going from evidence to recommendations. BMJ, 2008. 336: 1049.
https://www.ncbi.nlm.nih.gov/pubmed/18467413
7.WHO Classification of Tumours Editorial Board, Urinary and Male Genital Tumours. WHO Classification of Tumours, 5th Edn. Vol. 8. 2022.
https://www.iarc.who.int/news-events/who-classification-of-tumours-5th-edition-volume-8-urinary-and-male-genital-tumours/
8.Sanchez, D.F., et al. Pathological factors, behavior, and histological prognostic risk groups in subtypes of penile squamous cell carcinomas (SCC). Semin Diagn Pathol, 2015. 32: 222.
https://www.ncbi.nlm.nih.gov/pubmed/25677263
9.Thomas, A., et al. Penile cancer. Nat Rev Dis Primers, 2021. 7: 11.
https://www.ncbi.nlm.nih.gov/pubmed/33574340
10.Fu, L., et al. Global Pattern and Trends in Penile Cancer Incidence: Population-Based Study. JMIR Public Health Surveill, 2022. 8: e34874.
https://www.ncbi.nlm.nih.gov/pubmed/35793140
11.International Agency for Research on Cancer (IARC). Cancer Today. 2020. 2025.
https://gco.iarc.fr/today/home
12.Parkin, D.M., et al. Chapter 2: The burden of HPV-related cancers. Vaccine, 2006. 24 Suppl 3: S3/11.
https://www.ncbi.nlm.nih.gov/pubmed/16949997
13.Cho, S., et al. Twenty-two-year incidence trend of urological cancers in the Republic of Korea: 1999-2020. Investig Clin Urol, 2024. 65: 23.
https://www.ncbi.nlm.nih.gov/pubmed/38197748
14.Wnetrzak, I., et al. Epidemiology of penile cancer in Poland compared to other European countries. Cancer Med, 2024. 13: e70092.
https://www.ncbi.nlm.nih.gov/pubmed/39164960
15.Hansen, B.T., et al. Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956-2015. Int J Cancer, 2018. 142: 1586.
https://www.ncbi.nlm.nih.gov/pubmed/29205336
16.Moen, C.A., et al. Penile Cancers Attributed to Human Papillomavirus Are Associated with Improved Survival for Node-positive Patients. Findings from a Norwegian Cohort Study Spanning 50 Years. Eur Urol Oncol, 2024. 7: 778.
https://www.ncbi.nlm.nih.gov/pubmed/37949729
17.Moen, C.A., et al. The past, present and future of penile cancer in the Nordic countries. Results from NORDCAN. BJUI Compass, 2025. 6: e70041.
https://www.ncbi.nlm.nih.gov/pubmed/40584288
18.Boehm, W.U., et al. The Clinical Complexity of Penile Cancer: Current Clinical-Epidemiological Data from the Database of the Free State of Saxony/Germany. Urol Int, 2022. 106: 706.
https://www.ncbi.nlm.nih.gov/pubmed/34700316
19.Vreeburg, M.T.A., et al. Penile cancer care in the Netherlands: increased incidence, centralisation, and improved survival. BJU Int, 2024. 133: 596.
https://www.ncbi.nlm.nih.gov/pubmed/38403729
20.Cancer Research UK. Penile Cancer incidence trends over time. 2022.
https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/penile-cancer/incidence#heading-Two
21.Daubisse-Marliac, L., et al. Long-term trends in incidence and survival of penile cancer in France. Cancer Epidemiol, 2017. 50: 125.
https://www.ncbi.nlm.nih.gov/pubmed/28898817
22.Backes, D.M., et al. Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control, 2009. 20: 449.
https://www.ncbi.nlm.nih.gov/pubmed/19082746
23.Qi, F., et al. Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data. Ann Transl Med, 2020. 8: 1428.
https://www.ncbi.nlm.nih.gov/pubmed/33313173
24.Wenzel, M., et al. Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma. Cancer Causes Control, 2022. 33: 25.
https://www.ncbi.nlm.nih.gov/pubmed/34476653
25.Chaux, A., et al. Epidemiologic profile, sexual history, pathologic features, and human papillomavirus status of 103 patients with penile carcinoma. World J Urol, 2013. 31: 861.
https://www.ncbi.nlm.nih.gov/pubmed/22116602
26.Barnholtz-Sloan, J.S., et al. Incidence trends in primary malignant penile cancer. Urol Oncol, 2007. 25: 361.
https://www.ncbi.nlm.nih.gov/pubmed/17826651
27.Hartwig, S., et al. Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review. BMC Cancer, 2012. 12: 30.
https://www.ncbi.nlm.nih.gov/pubmed/22260541
28.Olesen, T.B., et al. Prevalence of human papillomavirus DNA and p16(INK4a) in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol, 2019. 20: 145.
https://www.ncbi.nlm.nih.gov/pubmed/30573285
29.Xu, L., et al. Projected oropharyngeal carcinoma incidence among middle-aged US men. Head Neck, 2019. 41: 3226.
https://www.ncbi.nlm.nih.gov/pubmed/31125167
30.The Global Cancer Observatory. 26-Penis Fact Sheet. 2022.
https://gco.iarc.fr/today/data/factsheets/cancers/26-Penis-fact-sheet.pdf
31.Douglawi, A., et al. Updates on the epidemiology and risk factors for penile cancer. Transl Androl Urol, 2017. 6: 785.
https://www.ncbi.nlm.nih.gov/pubmed/29184774
32.Deng, X., et al. Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study. Front Oncol, 2022. 12: 891623.
https://www.ncbi.nlm.nih.gov/pubmed/35785206
33.Lebelo, R.L., et al. Diversity of HPV types in cancerous and pre-cancerous penile lesions of South African men: implications for future HPV vaccination strategies. J Med Virol, 2014. 86: 257.
https://www.ncbi.nlm.nih.gov/pubmed/24155172
34.Stankiewicz, E., et al. HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis. Mod Pathol, 2009. 22: 1160.
https://www.ncbi.nlm.nih.gov/pubmed/19465901
35.Kayes, O., et al. Molecular and genetic pathways in penile cancer. Lancet Oncol, 2007. 8: 420.
https://www.ncbi.nlm.nih.gov/pubmed/17466899
36.Nordenvall, C., et al. Cancer risk among patients with condylomata acuminata. Int J Cancer, 2006. 119: 888.
https://www.ncbi.nlm.nih.gov/pubmed/16557590
37.Lont, A.P., et al. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival. Int J Cancer, 2006. 119: 1078.
https://www.ncbi.nlm.nih.gov/pubmed/16570278
38.Bezerra, A.L., et al. Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. Cancer, 2001. 91: 2315.
https://www.ncbi.nlm.nih.gov/pubmed/11413520
39.Bandini, M., et al. Association Between Human Papillomavirus Infection and Outcome of Perioperative Nodal Radiotherapy for Penile Carcinoma. Eur Urol Oncol, 2021. 4: 802.
https://www.ncbi.nlm.nih.gov/pubmed/33199252
40.Holters, S., et al. Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma. Virchows Arch, 2019. 475: 211.
https://www.ncbi.nlm.nih.gov/pubmed/30972551
41.Sand, F.L., et al. Prognostic Significance of HPV and p16 Status in Men Diagnosed with Penile Cancer: A Systematic Review and Meta-analysis. Cancer Epidemiol Biomarkers Prev, 2018. 27: 1123.
https://www.ncbi.nlm.nih.gov/pubmed/29987099
42.Liu, H., et al. Human papillomavirus as a favorable prognostic factor in a subset of head and neck squamous cell carcinomas: A meta-analysis. J Med Virol, 2017. 89: 710.
https://www.ncbi.nlm.nih.gov/pubmed/27575972
43.Urbute, A., et al. Prognostic Significance of HPV DNA and p16(INK4a) in Anal Cancer: A Systematic Review and Meta-Analysis. Cancer Epidemiol Biomarkers Prev, 2020. 29: 703.
https://www.ncbi.nlm.nih.gov/pubmed/32051192
44.Zhang, J., et al. Prognostic Significance of P16(INK4a) Expression in Penile Squamous Cell Carcinoma: A Meta-Analysis with Trial Sequential Analysis. Biomed Res Int, 2018. 2018: 8345893.
https://www.ncbi.nlm.nih.gov/pubmed/30105253
45.Chahoud, J., et al. Prognostic Significance of p16 and Its Relationship with Human Papillomavirus Status in Patients with Penile Squamous Cell Carcinoma: Results of 5 Years Follow-Up. Cancers (Basel), 2022. 14.
https://www.ncbi.nlm.nih.gov/pubmed/36551510
46.Sand, F.L., et al. The prognostic value of p16 and p53 expression for survival after vulvar cancer: A systematic review and meta-analysis. Gynecol Oncol, 2019. 152: 208.
https://www.ncbi.nlm.nih.gov/pubmed/30415992
47.Mirghani, H., et al. Is there an increased risk of cancer among spouses of patients with an HPV-related cancer: A systematic review. Oral Oncol, 2017. 67: 138.
https://www.ncbi.nlm.nih.gov/pubmed/28351568
48.de Bruijn, R.E., et al. Patients with penile cancer and the risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis. BJU Int, 2013. 112: 905.
https://www.ncbi.nlm.nih.gov/pubmed/23905914
49.Elst, L., et al. Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization. Eur Urol, 2024. 86: 114.
https://www.ncbi.nlm.nih.gov/pubmed/38670879
50.Sand, F.L., et al. The prognostic value of p53 and Ki-67 expression status in penile cancer: a systematic review and meta-analysis. Pathology, 2025. 57: 276.
https://www.ncbi.nlm.nih.gov/pubmed/39939228
51.Chahoud, J., et al. TP53 Mutations Emerge as a Critical Biomarker in Penile Cancer, Superseding Human Papillomavirus Status. Eur Urol, 2024. 86: 128.
https://www.ncbi.nlm.nih.gov/pubmed/38749849
52.Monteiro, F.S.M., et al. Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study. Oncologist, 2025. 30.
https://www.ncbi.nlm.nih.gov/pubmed/39222919
53.Li, Y., et al. Impact of TP53 Alterations on Clinical Outcomes in Penile Squamous Cell Carcinoma. Clin Genitourin Cancer, 2025. 23: 102323.
https://www.ncbi.nlm.nih.gov/pubmed/40240224
54.Nazha, B., et al. Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers. Cancer, 2023. 129: 3884.
https://www.ncbi.nlm.nih.gov/pubmed/37565840
55.Starita, N., et al. Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients. Int J Cancer, 2022. 150: 1879.
https://www.ncbi.nlm.nih.gov/pubmed/35253909
56.da Silva Santos, R., et al. Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection. Epigenetics, 2024. 19: 2305081.
https://www.ncbi.nlm.nih.gov/pubmed/38245880
57.Ermakov, M.S., et al. Different Mutational Landscapes in Human Papillomavirus-Induced and Human Papillomavirus-Independent Invasive Penile Squamous Cell Cancers. Mod Pathol, 2023. 36: 100250.
https://www.ncbi.nlm.nih.gov/pubmed/37353203
58.Hrudka, J., et al. Immune cell infiltration, tumour budding, and the p53 expression pattern are important predictors in penile squamous cell carcinoma: a retrospective study of 152 cases. Pathology, 2023. 55: 637.
https://www.ncbi.nlm.nih.gov/pubmed/37316384
59.Necchi, A., et al. Genomic Profiles and Clinical Outcomes of Penile Squamous Cell Carcinoma With Elevated Tumor Mutational Burden. JAMA Netw Open, 2023. 6: e2348002.
https://www.ncbi.nlm.nih.gov/pubmed/38150257
60.Trias, I., et al. p53 Immunohistochemistry Defines a Subset of Human Papillomavirus-Independent Penile Squamous Cell Carcinomas With Adverse Prognosis. Am J Surg Pathol, 2024. 48: 1439.
https://www.ncbi.nlm.nih.gov/pubmed/39040011
61.Zhang, J., et al. The efficacy of vaccination to prevent human papilloma viruses infection at anal and oral: a systematic review and meta-analysis. Public Health, 2021. 196: 165.
https://www.ncbi.nlm.nih.gov/pubmed/34229128
62.Harder, T., et al. Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review. BMC Med, 2018. 16: 110.
https://www.ncbi.nlm.nih.gov/pubmed/30016957
63.Liao, C.I., et al. Trends in Human Papillomavirus-Associated Cancers, Demographic Characteristics, and Vaccinations in the US, 2001-2017. JAMA Netw Open, 2022. 5: e222530.
https://www.ncbi.nlm.nih.gov/pubmed/35294540
64.Elst, L., et al. HPV Vaccination: Does It Have a Role in Preventing Penile Cancer and Other Preneoplastic Lesions? Semin Oncol Nurs, 2022. 38: 151284.
https://www.ncbi.nlm.nih.gov/pubmed/35577640
65.Tsen, H.F., et al. Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). Cancer Causes Control, 2001. 12: 267.
https://www.ncbi.nlm.nih.gov/pubmed/11405332
66.Koifman, L., et al. Epidemiological aspects of penile cancer in Rio de Janeiro: evaluation of 230 cases. Int Braz J Urol, 2011. 37: 231.
https://www.ncbi.nlm.nih.gov/pubmed/21557840
67.Van Howe, R.S., et al. The carcinogenicity of smegma: debunking a myth. J Eur Acad Dermatol Venereol, 2006. 20: 1046.
https://www.ncbi.nlm.nih.gov/pubmed/16987256
68.Daling, J.R., et al. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer, 2005. 116: 606.
https://www.ncbi.nlm.nih.gov/pubmed/15825185
69.Velazquez, E.F., et al. Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol, 2004. 12: 139.
https://www.ncbi.nlm.nih.gov/pubmed/15173919
70.Velazquez, E.F., et al. Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol, 2003. 27: 1448.
https://www.ncbi.nlm.nih.gov/pubmed/14576478
71.Teichman, J.M., et al. Noninfectious penile lesions. Am Fam Physician, 2010. 81: 167.
https://www.ncbi.nlm.nih.gov/pubmed/20082512
72.Renaud-Vilmer, C., et al. Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma. J Am Acad Dermatol, 2010. 62: 284.
https://www.ncbi.nlm.nih.gov/pubmed/20115951
73.Straub Hogan, M.M., et al. Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series. Mod Pathol, 2022. 35: 1101.
https://www.ncbi.nlm.nih.gov/pubmed/35190664
74.Menon, S., et al. International Society of Urological Pathology (ISUP) Multidisciplinary Consensus on Premalignant and Putative Precursor Lesions of Penile Cancer: Working Group 5 report on Terminology, Grading, and Molecular Testing Practices. Am J Surg Pathol, 2025.
https://www.ncbi.nlm.nih.gov/pubmed/40826809
75.Moch, H., et al. The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol, 2022. 82: 458.
https://www.ncbi.nlm.nih.gov/pubmed/35853783
76.Chaux, A., et al. Metastatic tumors to the penis: a report of 17 cases and review of the literature. Int J Surg Pathol, 2011. 19: 597.
https://www.ncbi.nlm.nih.gov/pubmed/20075023
77.Ebel, J.J., et al. Whole-mount evaluation of penectomies for penile cancer: feasibility, cost and comparison to routine sectioning. Histopathology, 2013. 63: 64.
https://www.ncbi.nlm.nih.gov/pubmed/23738630
78.Corbishley C., et al. Standards and datasets for reporting cancers Dataset for penile and distal urethral cancer histopathology reports. 2022.
https://www.rcpath.org/uploads/assets/d0e70985-300e-4835-af4583df56025869/Dataset-for-penile-and-distal-urethral-cancer-histopathology-reports.pdf
79.Tang, V., et al. Should centralized histopathological review in penile cancer be the global standard? BJU Int, 2014. 114: 340.
https://www.ncbi.nlm.nih.gov/pubmed/24053106
80.Vanthoor, J., et al. Making surgery safer by centralization of care: impact of case load in penile cancer. World J Urol, 2020. 38: 1385.
https://www.ncbi.nlm.nih.gov/pubmed/31292733
81.Aumayr, K., et al. P16INK4A immunohistochemistry for detection of human papilloma virus-associated penile squamous cell carcinoma is superior to in-situ hybridization. Int J Immunopathol Pharmacol, 2013. 26: 611.
https://www.ncbi.nlm.nih.gov/pubmed/24067458
82.Bezerra, S.M., et al. Human papillomavirus infection and immunohistochemical p16(INK4a) expression as predictors of outcome in penile squamous cell carcinomas. Hum Pathol, 2015. 46: 532.
https://www.ncbi.nlm.nih.gov/pubmed/25661481
83.Mannweiler, S., et al. Two major pathways of penile carcinogenesis: HPV-induced penile cancers overexpress p16ink4a, HPV-negative cancers associated with dermatoses express p53, but lack p16ink4a overexpression. J Am Acad Dermatol, 2013. 69: 73.
https://www.ncbi.nlm.nih.gov/pubmed/23474228
84.Corbishley, M.C., et al. Carcinoma of the Penis and Distal Urethra Histopathology Reporting Guide 1st edition. International Collaboration on Cancer Reporting; Sydney, Australia. ISBN: 978-1-925687-05-7. 2017.
https://www.iccr-cancer.org/datasets/published-datasets/urinary-male-genital/penis/
85.Guimaraes, G.C., et al. Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases. Urology, 2006. 68: 148.
https://www.ncbi.nlm.nih.gov/pubmed/16844455
86.Sanchez, D.F., et al. What Is New in the Pathologic Staging of Penile Carcinoma in the 8th Edition of AJCC TNM Model: Rationale for Changes With Practical Stage-by-stage Category Diagnostic Considerations. Adv Anat Pathol, 2021. 28: 209.
https://www.ncbi.nlm.nih.gov/pubmed/34050061
87.Sali, A.P., et al. Histopathological risk scoring system as a tool for predicting lymph nodal metastasis in penile squamous cell carcinoma. Pathology, 2019. 51: 696.
https://www.ncbi.nlm.nih.gov/pubmed/31635947
88.Winters, B.R., et al. Predictors of Nodal Upstaging in Clinical Node Negative Patients With Penile Carcinoma: A National Cancer Database Analysis. Urology, 2016. 96: 29.
https://www.ncbi.nlm.nih.gov/pubmed/27450944
89.Feng, M.A., et al. Concordance of lymphovascular invasion diagnosed in penile carcinoma with and without the immunohistochemical markers ERG and CD31. Histol Histopathol, 2016. 31: 293.
https://www.ncbi.nlm.nih.gov/pubmed/26452171
90.Dorofte, L., et al. Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care. Virchows Arch, 2022. 480: 879.
https://www.ncbi.nlm.nih.gov/pubmed/34889977
91.Aita, G., et al. Pattern of invasion is the most important prognostic factor in patients with penile cancer submitted to lymph node dissection and pathological absence of lymph node metastasis. BJU Int, 2015. 116: 584.
https://www.ncbi.nlm.nih.gov/pubmed/25639616
92.Dorofte, L., et al. New histological risk grading system for prediction of lymph node metastasis in patients with penile cancer. Virchows Arch, 2025. 486: 759.
https://www.ncbi.nlm.nih.gov/pubmed/39251424
93.Cubilla, A.L. The role of pathologic prognostic factors in squamous cell carcinoma of the penis. World J Urol, 2009. 27: 169.
https://www.ncbi.nlm.nih.gov/pubmed/18766352
94.Zekan, D.S., et al. Prognostic predictors of lymph node metastasis in penile cancer: a systematic review. Int Braz J Urol, 2021. 47: 943.
https://www.ncbi.nlm.nih.gov/pubmed/33650835
95.Fankhauser, C.D., et al. Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer. J Cancer Res Clin Oncol, 2022. 148: 2231.
https://www.ncbi.nlm.nih.gov/pubmed/35411405
96.Brierley, J., et al., TNM Classification of Malignant Tumours, 9th Edn. 2025.
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1444332414.html
97.Li, Z., et al. Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis. J Cancer, 2021. 12: 1960.
https://www.ncbi.nlm.nih.gov/pubmed/33753994
98.Sali, A.P., et al. A comparative study of AJCC and the modified staging system in pT2/pT3 penile squamous cell carcinoma - a validation on an external data set. Histopathology, 2022. 80: 566.
https://www.ncbi.nlm.nih.gov/pubmed/34586682
99.Zhang, Z.L., et al. The importance of extranodal extension in penile cancer: a meta-analysis. BMC Cancer, 2015. 15: 815.
https://www.ncbi.nlm.nih.gov/pubmed/26510975
100.Gunia, S., et al. Does the width of the surgical margin of safety or premalignant dermatoses at the negative surgical margin affect outcome in surgically treated penile cancer? J Clin Pathol, 2014. 67: 268.
https://www.ncbi.nlm.nih.gov/pubmed/24100380
101.Wang, J.Y., et al. Prognostic significance of the degree of extranodal extension in patients with penile carcinoma. Asian J Androl, 2014. 16: 437.
https://www.ncbi.nlm.nih.gov/pubmed/24480925
102.Chaux, A., et al. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol, 2009. 33: 1049.
https://www.ncbi.nlm.nih.gov/pubmed/19384188
103.Zito Marino, F., et al. Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study. Infect Agent Cancer, 2021. 16: 22.
https://www.ncbi.nlm.nih.gov/pubmed/33789689
104.Cubilla, A.L., et al. Value of p16(INK)(4)(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases. Am J Surg Pathol, 2011. 35: 253.
https://www.ncbi.nlm.nih.gov/pubmed/21263246
105.Canete-Portillo, S., et al. Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers V: Recommendations on the Use of Immunohistochemical and Molecular Biomarkers in Penile Cancer. Am J Surg Pathol, 2020. 44: e80.
https://www.ncbi.nlm.nih.gov/pubmed/32235153
106.Amin, M.B., et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin, 2017. 67: 93.
https://www.ncbi.nlm.nih.gov/pubmed/28094848
107.Velazquez, E.F., et al. Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol, 2008. 32: 974.
https://www.ncbi.nlm.nih.gov/pubmed/18460979
108.Leijte, J.A., et al. Evaluation of current TNM classification of penile carcinoma. J Urol, 2008. 180: 933.
https://www.ncbi.nlm.nih.gov/pubmed/18635216
109.Sun, M., et al. Development and external validation of a prognostic tool for prediction of cancer-specific mortality after complete loco-regional pathological staging for squamous cell carcinoma of the penis. BJU Int, 2015. 116: 734.
https://www.ncbi.nlm.nih.gov/pubmed/24552303
110.Li, Z.S., et al. Modification of N staging systems for penile cancer: a more precise prediction of prognosis. Br J Cancer, 2015. 113: 1746.
https://www.ncbi.nlm.nih.gov/pubmed/26695555
111.Chipollini, J., et al. Patient presentation, differential diagnosis, and management of penile lesions. Can Urol Assoc J, 2019. 13: S2.
https://www.ncbi.nlm.nih.gov/pubmed/31237837
112.Lont, A.P., et al. A comparison of physical examination and imaging in determining the extent of primary penile carcinoma. BJU Int, 2003. 91: 493.
https://www.ncbi.nlm.nih.gov/pubmed/12656901
113.Bertolotto, M., et al. Primary and secondary malignancies of the penis: ultrasound features. Abdom Imaging, 2005. 30: 108.
https://www.ncbi.nlm.nih.gov/pubmed/15759326
114.Kayes, O., et al. The role of magnetic resonance imaging in the local staging of penile cancer. Eur Urol, 2007. 51: 1313.
https://www.ncbi.nlm.nih.gov/pubmed/17113213
115.Hanchanale, V., et al. The accuracy of magnetic resonance imaging (MRI) in predicting the invasion of the tunica albuginea and the urethra during the primary staging of penile cancer. BJU Int, 2016. 117: 439.
https://www.ncbi.nlm.nih.gov/pubmed/25600638
116.Krishna, S., et al. Diagnostic Accuracy of MRI in Local Staging (T Category) of Penile Cancer and the Value of Artificial Erection: A Systematic Review and Meta-Analysis. AJR Am J Roentgenol, 2022. 219: 28.
https://www.ncbi.nlm.nih.gov/pubmed/35195435
117.Bozzini, G., et al. Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients: Results From a Large Prospective Multicenter European Study. Urology, 2016. 90: 131.
https://www.ncbi.nlm.nih.gov/pubmed/26776562
118.Wood, H.M., et al. Anatomic considerations of the penis, lymphatic drainage, and biopsy of the sentinel node. Urol Clin North Am, 2010. 37: 327.
https://www.ncbi.nlm.nih.gov/pubmed/20674689
119.Horenblas, S., et al. Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: analysis of tumor, nodes and metastasis classification system. J Urol, 1994. 151: 1239.
https://www.ncbi.nlm.nih.gov/pubmed/8158767
120.Srinivas, V., et al. Penile cancer: relation of extent of nodal metastasis to survival. J Urol, 1987. 137: 880.
https://www.ncbi.nlm.nih.gov/pubmed/3573181
121.Kroon, B.K., et al. Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol, 2005. 173: 816.
https://www.ncbi.nlm.nih.gov/pubmed/15711276
122.Horenblas, S., et al. Squamous cell carcinoma of the penis. II. Treatment of the primary tumor. J Urol, 1992. 147: 1533.
https://www.ncbi.nlm.nih.gov/pubmed/1593683
123.Woldu, S.L., et al. Usage and survival implications of surgical staging of inguinal lymph nodes in intermediate- to high-risk, clinical localized penile cancer: A propensity-score matched analysis. Urol Oncol, 2018. 36: 159 e7.
https://www.ncbi.nlm.nih.gov/pubmed/29288008
124.Mueller-Lisse, U.G., et al. Functional imaging in penile cancer: PET/computed tomography, MRI, and sentinel lymph node biopsy. Curr Opin Urol, 2008. 18: 105.
https://www.ncbi.nlm.nih.gov/pubmed/18090498
125.Leijte, J.A., et al. Prospective evaluation of hybrid 18F-fluorodeoxyglucose positron emission tomography/computed tomography in staging clinically node-negative patients with penile carcinoma. BJU Int, 2009. 104: 640.
https://www.ncbi.nlm.nih.gov/pubmed/19281465
126.Schlenker, B., et al. Detection of inguinal lymph node involvement in penile squamous cell carcinoma by 18F-fluorodeoxyglucose PET/CT: a prospective single-center study. Urol Oncol, 2012. 30: 55.
https://www.ncbi.nlm.nih.gov/pubmed/20022269
127.Jakobsen, J.K., et al. DaPeCa-7: comparative assessment of fluorodeoxyglucose positron emission tomography/computed tomography (CT) and conventional diagnostic CT in diagnosis of lymph node metastases, distant metastases and incidental findings in patients with invasive penile cancer. BJU Int, 2021. 127: 254.
https://www.ncbi.nlm.nih.gov/pubmed/33448605
128.Sadeghi, R., et al. Accuracy of 18F-FDG PET/CT for diagnosing inguinal lymph node involvement in penile squamous cell carcinoma: systematic review and meta-analysis of the literature. Clin Nucl Med, 2012. 37: 436.
https://www.ncbi.nlm.nih.gov/pubmed/22475891
129.Krishna, R.P., et al. Sonography: an underutilized diagnostic tool in the assessment of metastatic groin nodes. J Clin Ultrasound, 2008. 36: 212.
https://www.ncbi.nlm.nih.gov/pubmed/17960822
130.Kroon, B.K., et al. Ultrasonography-guided fine-needle aspiration cytology before sentinel node biopsy in patients with penile carcinoma. BJU Int, 2005. 95: 517.
https://www.ncbi.nlm.nih.gov/pubmed/15705071
131.Lee, E.W.C., et al. High diagnostic accuracy of inguinal ultrasonography and fine-needle aspiration followed by dynamic sentinel lymph node biopsy in men with impalpable and palpable inguinal lymph nodes. BJU Int, 2022. 130: 331.
https://www.ncbi.nlm.nih.gov/pubmed/35098622
132.Graafland, N.M., et al. Prognostic factors for occult inguinal lymph node involvement in penile carcinoma and assessment of the high-risk EAU subgroup: a two-institution analysis of 342 clinically node-negative patients. Eur Urol, 2010. 58: 742.
https://www.ncbi.nlm.nih.gov/pubmed/20800339
133.Catalona, W.J. Modified inguinal lymphadenectomy for carcinoma of the penis with preservation of saphenous veins: technique and preliminary results. J Urol, 1988. 140: 306.
https://www.ncbi.nlm.nih.gov/pubmed/3398125
134.Protzel, C., et al. Lymphadenectomy in the surgical management of penile cancer. Eur Urol, 2009. 55: 1075.
https://www.ncbi.nlm.nih.gov/pubmed/19264390
135.d’Ancona, C.A., et al. Long-term followup of penile carcinoma treated with penectomy and bilateral modified inguinal lymphadenectomy. J Urol, 2004. 172: 498.
https://www.ncbi.nlm.nih.gov/pubmed/15247713
136.Thyavihally, Y.B., et al. Comparative study of perioperative and survival outcomes after video endoscopic inguinal lymphadenectomy (VEIL) and open inguinal lymph node dissection (O-ILND) in the management of inguinal lymph nodes in carcinoma of the penis. J Robot Surg, 2021. 15: 905.
https://www.ncbi.nlm.nih.gov/pubmed/33484414
137.Wever, L., et al. Incidence and risk factor analysis of complications after sentinel node biopsy for penile cancer. BJU Int, 2022. 130: 486.
https://www.ncbi.nlm.nih.gov/pubmed/35257463
138.Gopman, J.M., et al. Predicting postoperative complications of inguinal lymph node dissection for penile cancer in an international multicentre cohort. BJU Int, 2015. 116: 196.
https://www.ncbi.nlm.nih.gov/pubmed/25777366
139.Gomez-Ferrer, A., et al. A single-center comparison of our initial experiences in treating penile and urethral cancer with video-endoscopic inguinal lymphadenectomy (VEIL) and later experiences in melanoma cases. Front Surg, 2022. 9: 870857.
https://www.ncbi.nlm.nih.gov/pubmed/36225221
140.Munoz Guillermo, V., et al. [Video endoscopic inguinal lymphadenectomy in penile cancer: Systematic review.]. Arch Esp Urol, 2019. 72: 992.
https://www.ncbi.nlm.nih.gov/pubmed/31823847
141.Horenblas, S., et al. Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure. J Urol, 2000. 163: 100.
https://www.ncbi.nlm.nih.gov/pubmed/10604324
142.de Vries, H.M., et al. Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation. BJU Int, 2022. 130: 126.
https://www.ncbi.nlm.nih.gov/pubmed/34927790
143.Dell’Oglio, P., et al. Hybrid Indocyanine Green-(99m)Tc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution. Eur Urol, 2020. 78: 865.
https://www.ncbi.nlm.nih.gov/pubmed/32950298
144.Leijte, J.A., et al. Reliability and safety of current dynamic sentinel node biopsy for penile carcinoma. Eur Urol, 2007. 52: 170.
https://www.ncbi.nlm.nih.gov/pubmed/17316967
145.Zou, Z.J., et al. Radiocolloid-based dynamic sentinel lymph node biopsy in penile cancer with clinically negative inguinal lymph node: an updated systematic review and meta-analysis. Int Urol Nephrol, 2016. 48: 2001.
https://www.ncbi.nlm.nih.gov/pubmed/27577753
146.Hughes, B., et al. Non-invasive and minimally invasive staging of regional lymph nodes in penile cancer. World J Urol, 2009. 27: 197.
https://www.ncbi.nlm.nih.gov/pubmed/18594830
147.Hovels, A.M., et al. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol, 2008. 63: 387.
https://www.ncbi.nlm.nih.gov/pubmed/18325358
148.Antoch, G., et al. Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. J Clin Oncol, 2004. 22: 4357.
https://www.ncbi.nlm.nih.gov/pubmed/15514377
149.Graafland, N.M., et al. Scanning with 18F-FDG-PET/CT for detection of pelvic nodal involvement in inguinal node-positive penile carcinoma. Eur Urol, 2009. 56: 339.
https://www.ncbi.nlm.nih.gov/pubmed/19477581
150.Johnstone, P.A.S., et al. Changing Radiotherapy Paradigms in Penile Cancer. Eur Urol Open Sci, 2022. 36: 47.
https://www.ncbi.nlm.nih.gov/pubmed/35028598
151.Scott, J.G., et al. Pan-cancer prediction of radiotherapy benefit using genomic-adjusted radiation dose (GARD): a cohort-based pooled analysis. Lancet Oncol, 2021. 22: 1221.
https://www.ncbi.nlm.nih.gov/pubmed/34363761
152.Sakalis, V.I., et al. What Is the Most Effective Management of the Primary Tumor in Men with Invasive Penile Cancer: A Systematic Review of the Available Treatment Options and Their Outcomes. Eur Urol Open Sci, 2022. 40: 58.
https://www.ncbi.nlm.nih.gov/pubmed/35540709
153.Ashley, S., et al. Human Papilloma Virus (HPV) status may impact treatment outcomes in patients with pre-cancerous penile lesions (an eUROGEN Study). Int J Impot Res, 2021. 33: 620.
https://www.ncbi.nlm.nih.gov/pubmed/32710000
154.Hoekstra, R.J., et al. Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands. Int J Urol, 2019. 26: 353.
https://www.ncbi.nlm.nih.gov/pubmed/30508877
155.Kravvas, G., et al. The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature. J Dermatolog Treat, 2022. 33: 1047.
https://www.ncbi.nlm.nih.gov/pubmed/32705920
156.Kristiansen, S., et al. Incidence of penile intraepithelial neoplasia and treatment strategies in Sweden 2000-2019. BJU Int, 2022. 129: 752.
https://www.ncbi.nlm.nih.gov/pubmed/35044047
157.Alnajjar, H.M., et al. Treatment of carcinoma in situ of the glans penis with topical chemotherapy agents. Eur Urol, 2012. 62: 923.
https://www.ncbi.nlm.nih.gov/pubmed/22421082
158.Issa, A., et al. Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review. Eur Urol Focus, 2022. 8: 829.
https://www.ncbi.nlm.nih.gov/pubmed/33994168
159.Work, G., et al. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol, 2018. 78: 560.
https://www.ncbi.nlm.nih.gov/pubmed/29331386
160.Leone, A., et al. Need for Evidence and Consensus on Laser Treatment for Management of Select Primary Penile Tumors. Eur Urol, 2017. 72: 4.
https://www.ncbi.nlm.nih.gov/pubmed/28131464
161.Shaw, K.S., et al. Combination of imiquimod with cryotherapy in the treatment of penile intraepithelial neoplasia. JAAD Case Rep, 2017. 3: 546.
https://www.ncbi.nlm.nih.gov/pubmed/29264388
162.Paoli, J., et al. Penile intraepithelial neoplasia: results of photodynamic therapy. Acta Derm Venereol, 2006. 86: 418.
https://www.ncbi.nlm.nih.gov/pubmed/16955186
163.Schlenker, B., et al. Organ-preserving neodymium-yttrium-aluminium-garnet laser therapy for penile carcinoma: a long-term follow-up. BJU Int, 2010. 106: 786.
https://www.ncbi.nlm.nih.gov/pubmed/20089106
164.Meijer, R.P., et al. Long-term follow-up after laser therapy for penile carcinoma. Urology, 2007. 69: 759.
https://www.ncbi.nlm.nih.gov/pubmed/17445665
165.Shabbir, M., et al. Glans resurfacing for the treatment of carcinoma in situ of the penis: surgical technique and outcomes. Eur Urol, 2011. 59: 142.
https://www.ncbi.nlm.nih.gov/pubmed/21050658
166.Caldamone, A.A., et al. Buccal mucosal grafts for urethral reconstruction. Urology, 1998. 51: 15.
https://www.ncbi.nlm.nih.gov/pubmed/9610551
167.Hakansson, U., et al. Organ-sparing reconstructive surgery in penile cancer: initial experiences at two Swedish referral centres. Scand J Urol, 2015. 49: 149.
https://www.ncbi.nlm.nih.gov/pubmed/25313620
168.Pang, K.H., et al. Advances in penile-sparing surgical approaches. Asian J Urol, 2022. 9: 359.
https://www.ncbi.nlm.nih.gov/pubmed/36381598
169.Cakir, O.O., et al. Surgical technique and outcomes following coronal-sparing glans resurfacing for benign and malignant penile lesions. Int J Impot Res, 2022. 34: 495.
https://www.ncbi.nlm.nih.gov/pubmed/34285385
170.Corbishley, C.M., et al. Glans resurfacing for precancerous and superficially invasive carcinomas of the glans penis: Pathological specimen handling and reporting. Semin Diagn Pathol, 2015. 32: 232.
https://www.ncbi.nlm.nih.gov/pubmed/25662797
171.Elst, L., et al. Local recurrence after glans-sparing surgery: no impact on penile cancer-specific survival. BJU Int, 2026. 137: 146.
https://www.ncbi.nlm.nih.gov/pubmed/41178285
172.Roussel, E., et al. Predictors of local recurrence and its impact on survival after glansectomy for penile cancer: time to challenge the dogma? BJU Int, 2021. 127: 606.
https://www.ncbi.nlm.nih.gov/pubmed/33180969
173.Djajadiningrat, R.S., et al. Penile sparing surgery for penile cancer-does it affect survival? J Urol, 2014. 192: 120.
https://www.ncbi.nlm.nih.gov/pubmed/24373799
174.Leijte, J.A., et al. Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol, 2008. 54: 161.
https://www.ncbi.nlm.nih.gov/pubmed/18440124
175.Agrawal, A., et al. The histological extent of the local spread of carcinoma of the penis and its therapeutic implications. BJU Int, 2000. 85: 299.
https://www.ncbi.nlm.nih.gov/pubmed/10671885
176.Minhas, S., et al. What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int, 2005. 96: 1040.
https://www.ncbi.nlm.nih.gov/pubmed/16225525
177.Philippou, P., et al. Conservative surgery for squamous cell carcinoma of the penis: resection margins and long-term oncological control. J Urol, 2012. 188: 803.
https://www.ncbi.nlm.nih.gov/pubmed/22818137
178.Sri, D., et al. A study into the association between local recurrence rates and surgical resection margins in organ-sparing surgery for penile squamous cell cancer. BJU Int, 2018. 122: 576.
https://www.ncbi.nlm.nih.gov/pubmed/29604228
179.Jazayeri, S.B., et al. Outcomes of PeIN at the surgical margin: insights from an organ-sparing penile cancer database. World J Urol, 2025. 43: 360.
https://www.ncbi.nlm.nih.gov/pubmed/40478443
180.Lee, E.W.C., et al. Risk of Local Recurrence in Men With Penile Intraepithelial Neoplasia in the Surgical Margin After Penile-sparing Surgery. J Urol, 2023. 210: 778.
https://www.ncbi.nlm.nih.gov/pubmed/37675864
181.Ellul, T., et al. Frozen section analysis for organ-conserving surgery in penile cancer: Assessing oncological outcomes and trends of local recurrence. Journal of Clinical Urology, 2020. 13: 419.
https://doi.org/10.1177/2051415820903192
182.Kamel, M.H., et al. Organ Sparing Surgery for Penile Cancer: A Systematic Review. J Urol, 2017. 198: 770.
https://www.ncbi.nlm.nih.gov/pubmed/28286072
183.Tang, D.H., et al. Laser ablation as monotherapy for penile squamous cell carcinoma: A multi-center cohort analysis. Urol Oncol, 2018. 36: 147.
https://www.ncbi.nlm.nih.gov/pubmed/29097087
184.Musi, G., et al. Thulium-yttrium-aluminium-garnet (Tm:YAG) laser treatment of penile cancer: oncological results, functional outcomes, and quality of life. World J Urol, 2018. 36: 265.
https://www.ncbi.nlm.nih.gov/pubmed/29197968
185.Falcone, M., et al. Total Glans Resurfacing for the Management of Superficial Penile Cancer: A Retrospective Cohort Analysis in a Tertiary Referral Center. Urology, 2020. 145: 281.
https://www.ncbi.nlm.nih.gov/pubmed/32683069
186.Perez, J., et al. Oncological and Functional Outcomes After Organ-Sparing Plastic Reconstructive Surgery for Penile Cancer. Urology, 2020. 142: 161.
https://www.ncbi.nlm.nih.gov/pubmed/32380155
187.O’Kelly, F., et al. A Prospective Study of Total Glans Resurfacing for Localized Penile Cancer to Maximize Oncologic and Functional Outcomes in a Tertiary Referral Network. J Urol, 2017. 197: 1258.
https://www.ncbi.nlm.nih.gov/pubmed/28027867
188.Pang, K.H., et al. Glansectomy and Reconstruction for Penile Cancer: A Systematic Review. Eur Urol Focus, 2022. 8: 1318.
https://www.ncbi.nlm.nih.gov/pubmed/34903488
189.Crook, J., et al. Penile brachytherapy: technical aspects and postimplant issues. Brachytherapy, 2010. 9: 151.
https://www.ncbi.nlm.nih.gov/pubmed/19854685
190.de Crevoisier, R., et al. Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys, 2009. 74: 1150.
https://www.ncbi.nlm.nih.gov/pubmed/19395183
191.Delaunay, B., et al. Brachytherapy for penile cancer: efficacy and impact on sexual function. Brachytherapy, 2014. 13: 380.
https://www.ncbi.nlm.nih.gov/pubmed/23896397
192.Kamsu-Kom, L., et al. Clinical Experience with Pulse Dose Rate Brachytherapy for Conservative Treatment of Penile Carcinoma and Comparison with Historical Data of Low Dose Rate Brachytherapy. Clin Oncol (R Coll Radiol), 2015. 27: 387.
https://www.ncbi.nlm.nih.gov/pubmed/26003455
193.Sharma, D.N., et al. High-dose-rate interstitial brachytherapy for T1-T2-stage penile carcinoma: short-term results. Brachytherapy, 2014. 13: 481.
https://www.ncbi.nlm.nih.gov/pubmed/25037912
194.Pohankova, D., et al. High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma. Klin Onkol, 2019. 32: 52.
https://www.ncbi.nlm.nih.gov/pubmed/30764630
195.Martz, N., et al. High-dose rate brachytherapy in localized penile cancer: 5-Year clinical outcome analysis. Clin Transl Radiat Oncol, 2021. 27: 89.
https://www.ncbi.nlm.nih.gov/pubmed/33537466
196.Kellas-Sleczka, S., et al. Nineteen-year single-center experience in 76 patients with penile cancer treated with high-dose-rate brachytherapy. Brachytherapy, 2019. 18: 493.
https://www.ncbi.nlm.nih.gov/pubmed/31101437
197.Rouscoff, Y., et al. High-dose rate brachytherapy in localized penile cancer: short-term clinical outcome analysis. Radiat Oncol, 2014. 9: 142.
https://www.ncbi.nlm.nih.gov/pubmed/24941956
198.Rishi, A., et al. Novel portable apparatus for outpatient high-dose-rate (HDR) brachytherapy in penile cancer. Brachytherapy, 2022. 21: 839.
https://www.ncbi.nlm.nih.gov/pubmed/35915039
199.Azrif, M., et al. External-beam radiotherapy in T1-2 N0 penile carcinoma. Clin Oncol (R Coll Radiol), 2006. 18: 320.
https://www.ncbi.nlm.nih.gov/pubmed/16703750
200.Rozan, R., et al. Interstitial brachytherapy for penile carcinoma: a multicentric survey (259 patients). Radiother Oncol, 1995. 36: 83.
https://www.ncbi.nlm.nih.gov/pubmed/7501816
201.Delannes, M., et al. Iridium-192 interstitial therapy for squamous cell carcinoma of the penis. Int J Radiat Oncol Biol Phys, 1992. 24: 479.
https://www.ncbi.nlm.nih.gov/pubmed/1399733
202.Hasan, S., et al. The role of brachytherapy in organ preservation for penile cancer: A meta-analysis and review of the literature. Brachytherapy, 2015. 14: 517.
https://www.ncbi.nlm.nih.gov/pubmed/25944394
203.Zouhair, A., et al. Radiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis? Eur J Cancer, 2001. 37: 198.
https://www.ncbi.nlm.nih.gov/pubmed/11166146
204.Cordoba, A., et al. Low-dose brachytherapy for early stage penile cancer: a 20-year single-institution study (73 patients). Radiat Oncol, 2016. 11: 96.
https://www.ncbi.nlm.nih.gov/pubmed/27464910
205.Gambachidze, D., et al. Long-term evaluation of urinary, sexual, and quality of life outcomes after brachytherapy for penile carcinoma. Brachytherapy, 2018. 17: 221.
https://www.ncbi.nlm.nih.gov/pubmed/29089276
206.Djajadiningrat, R.S., et al. Neoadjuvant taxane-based combination chemotherapy in patients with advanced penile cancer. Clin Genitourin Cancer, 2015. 13: 44.
https://www.ncbi.nlm.nih.gov/pubmed/25009098
207.Ottenhof, S.R., et al. Surgical and Oncological Outcomes in Patients After Vascularised Flap Reconstruction for Locoregionally Advanced Penile Cancer. Eur Urol Focus, 2019. 5: 867.
https://www.ncbi.nlm.nih.gov/pubmed/29433986
208.Pagliaro, L.C., et al. Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol, 2010. 28: 3851.
https://www.ncbi.nlm.nih.gov/pubmed/20625118
209.Pizzocaro, G., et al. Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results. Eur Urol, 2009. 55: 546.
https://www.ncbi.nlm.nih.gov/pubmed/18649992
210.Necchi, A., et al. Clinical Outcomes of Perioperative Chemotherapy in Patients With Locally Advanced Penile Squamous-Cell Carcinoma: Results of a Multicenter Analysis. Clin Genitourin Cancer, 2017. 15: 548.
https://www.ncbi.nlm.nih.gov/pubmed/28325636
211.Nicolai, N., et al. A Combination of Cisplatin and 5-Fluorouracil With a Taxane in Patients Who Underwent Lymph Node Dissection for Nodal Metastases From Squamous Cell Carcinoma of the Penis: Treatment Outcome and Survival Analyses in Neoadjuvant and Adjuvant Settings. Clin Genitourin Cancer, 2016. 14: 323.
https://www.ncbi.nlm.nih.gov/pubmed/26341040
212.Nicholson, S., et al. Phase II trial of docetaxel, cisplatin and 5FU chemotherapy in locally advanced and metastatic penis cancer (CRUK/09/001). Br J Cancer, 2013. 109: 2554.
https://www.ncbi.nlm.nih.gov/pubmed/24169355
213.Nicholson, S., et al. VinCaP: a phase II trial of vinflunine in locally advanced and metastatic squamous carcinoma of the penis. Br J Cancer, 2022. 126: 34.
https://www.ncbi.nlm.nih.gov/pubmed/34671131
214.Theodore, C., et al. A phase II multicentre study of irinotecan (CPT 11) in combination with cisplatin (CDDP) in metastatic or locally advanced penile carcinoma (EORTC PROTOCOL 30992). Ann Oncol, 2008. 19: 1304.
https://www.ncbi.nlm.nih.gov/pubmed/18417462
215.Azizi, M., et al. Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma? J Urol, 2020. 203: 1147.
https://www.ncbi.nlm.nih.gov/pubmed/31928407
216.Yi, X.Y., et al. Neoadjuvant chemotherapy for patients with locally advanced penile cancer: an updated evidence. Asian J Androl, 2022. 24: 180.
https://www.ncbi.nlm.nih.gov/pubmed/34975068
217.McComas, K., et al. Definitive Chemoradiotherapy for Locally Advanced, Lymph-node Positive, Nonmetastatic Penile Squamous Cell Carcinoma. Clin Genitourin Cancer, 2020. 18: e573.
https://www.ncbi.nlm.nih.gov/pubmed/32335061
218.Ottenhof, S.R., et al. A Prospective Study of Chemoradiotherapy as Primary Treatment in Patients With Locoregionally Advanced Penile Carcinoma. Int J Radiat Oncol Biol Phys, 2023. 117: 139.
https://www.ncbi.nlm.nih.gov/pubmed/37030606
219.Ottenhof, S.R., et al. Chemoradiation in the treatment of loco-regionally advanced penile cancer. European Urology Supplements, 2019. 18: e655.
https://www.sciencedirect.com/science/article/pii/S1569905619304841
220.Ornellas, A.A., et al. Surgical treatment of invasive squamous cell carcinoma of the penis: Brazilian National Cancer Institute long-term experience. J Surg Oncol, 2008. 97: 487.
https://www.ncbi.nlm.nih.gov/pubmed/18425779
221.Veeratterapillay, R., et al. Oncologic Outcomes of Penile Cancer Treatment at a UK Supraregional Center. Urology, 2015. 85: 1097.
https://www.ncbi.nlm.nih.gov/pubmed/25769781
222.Gotsadze, D., et al. Is conservative organ-sparing treatment of penile carcinoma justified? Eur Urol, 2000. 38: 306.
https://www.ncbi.nlm.nih.gov/pubmed/10940705
223.Daseler, E.H., et al. Radical excision of the inguinal and iliac lymph glands; a study based upon 450 anatomical dissections and upon supportive clinical observations. Surg Gynecol Obstet, 1948. 87: 679.
https://www.ncbi.nlm.nih.gov/pubmed/18120502
224.Leijte, J.A., et al. Anatomical mapping of lymphatic drainage in penile carcinoma with SPECT-CT: implications for the extent of inguinal lymph node dissection. Eur Urol, 2008. 54: 885.
https://www.ncbi.nlm.nih.gov/pubmed/18502024
225.Omorphos, S., et al. Zonal mapping of sentinel lymph nodes in penile cancer patients using fused SPECT/CT imaging and lymphoscintigraphy. Urol Oncol, 2018. 36: 530 e1.
https://www.ncbi.nlm.nih.gov/pubmed/30318180
226.Yao, K., et al. Lymph Node Mapping in Patients with Penile Cancer Undergoing Pelvic Lymph Node Dissection. J Urol, 2021. 205: 145.
https://www.ncbi.nlm.nih.gov/pubmed/32755338
227.Culkin, D.J., et al. Advanced penile carcinoma. J Urol, 2003. 170: 359.
https://www.ncbi.nlm.nih.gov/pubmed/12853775
228.Leewansangtong, S., et al. The risks of lymph node metastasis and the prognostic factors in carcinoma of the penis: analysis of 50 patients treated with bilateral ilioinguinal lymphadenectomy. J Med Assoc Thai, 2001. 84: 204.
https://www.ncbi.nlm.nih.gov/pubmed/11336079
229.Marconnet, L., et al. Long-term followup of penile carcinoma with high risk for lymph node invasion treated with inguinal lymphadenectomy. J Urol, 2010. 183: 2227.
https://www.ncbi.nlm.nih.gov/pubmed/20399455
230.Martin, T.G., et al. Inguinal Lymphadenectomy for Squamous Cell Cancer of the Penis—Experience of a UK Supra-Regional Network. British Journal of Medical and Surgical Urology, 2012. 5: 241.
https://doi.org/10.1016/j.bjmsu.2011.12.009
231.Joshi, S.S., et al. Treatment Trends and Outcomes for Patients With Lymph Node-Positive Cancer of the Penis. JAMA Oncol, 2018. 4: 643.
https://www.ncbi.nlm.nih.gov/pubmed/29494739
232.Johnson, T.V., et al. Extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancer patients: results from the Surveillance, Epidemiology, and End Results program. Cancer, 2010. 116: 2960.
https://www.ncbi.nlm.nih.gov/pubmed/20564401
233.Chang, E.K., et al. Underutilization of Surgical Standard of Care for Insured Men with Invasive Penile Cancer. Urol Pract, 2021. 8: 348.
https://www.ncbi.nlm.nih.gov/pubmed/33898656
234.Cindolo, L., et al. Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study. World J Urol, 2019. 37: 1649.
https://www.ncbi.nlm.nih.gov/pubmed/30377813
235.Fankhauser, C.D., et al. Practice Patterns Among Penile Cancer Surgeons Performing Dynamic Sentinel Lymph Node Biopsy and Radical Inguinal Lymph Node Dissection in Men with Penile Cancer: A eUROGEN Survey. Eur Urol Open Sci, 2021. 24: 39.
https://www.ncbi.nlm.nih.gov/pubmed/34337494
236.Yao, K., et al. Fascia lata preservation during inguinal lymphadenectomy for penile cancer: rationale and outcome. Urology, 2013. 82: 642.
https://www.ncbi.nlm.nih.gov/pubmed/23876593
237.Schifano, N., et al. Outcomes following radical inguinal lymphadenectomy for penile cancer using a fascial-sparing surgical technique. World J Urol, 2023. 41: 1581.
https://www.ncbi.nlm.nih.gov/pubmed/37019998
238.Chipollini, J., et al. Identifying an optimal lymph node yield for penile squamous cell carcinoma: prognostic impact of surgical dissection. BJU Int, 2020. 125: 82.
https://www.ncbi.nlm.nih.gov/pubmed/31356716
239.Li, Z.S., et al. Disease-specific survival after radical lymphadenectomy for penile cancer: prediction by lymph node count and density. Urol Oncol, 2014. 32: 893.
https://www.ncbi.nlm.nih.gov/pubmed/24994488
240.Mao, W., et al. More lymph node dissection improves survival in patients with newly diagnosed lymph node-positive penile cancer. Int Urol Nephrol, 2019. 51: 641.
https://www.ncbi.nlm.nih.gov/pubmed/30758771
241.Soodana-Prakash, N., et al. Lymph node yield as a predictor of overall survival following inguinal lymphadenectomy for penile cancer. Urol Oncol, 2018. 36: 471 e19.
https://www.ncbi.nlm.nih.gov/pubmed/30143385
242.Zhu, Y., et al. Population-based assessment of the number of lymph nodes removed in the treatment of penile squamous cell carcinoma. Urol Int, 2014. 92: 186.
https://www.ncbi.nlm.nih.gov/pubmed/24246932
243.Johnson, D.E., et al. Management of regional lymph nodes in penile carcinoma. Five-year results following therapeutic groin dissections. Urology, 1984. 24: 308.
https://www.ncbi.nlm.nih.gov/pubmed/6485188
244.Chipollini, J., et al. Delay to Inguinal Lymph Node Dissection Greater than 3 Months Predicts Poorer Recurrence-Free Survival for Patients with Penile Cancer. J Urol, 2017. 198: 1346.
https://www.ncbi.nlm.nih.gov/pubmed/28652123
245.Gulia, A.K., et al. Impact of delay in inguinal lymph node dissection in patients with carcinoma of penis. Indian J Cancer, 2009. 46: 214.
https://www.ncbi.nlm.nih.gov/pubmed/19574673
246.Hegarty, P.K., et al. Controversies in ilioinguinal lymphadenectomy. Urol Clin North Am, 2010. 37: 421.
https://www.ncbi.nlm.nih.gov/pubmed/20674697
247.Ravi, R. Morbidity following groin dissection for penile carcinoma. Br J Urol, 1993. 72: 941.
https://www.ncbi.nlm.nih.gov/pubmed/8306161
248.Koifman, L., et al. Radical open inguinal lymphadenectomy for penile carcinoma: surgical technique, early complications and late outcomes. J Urol, 2013. 190: 2086.
https://www.ncbi.nlm.nih.gov/pubmed/23770135
249.Stuiver, M.M., et al. Early wound complications after inguinal lymphadenectomy in penile cancer: a historical cohort study and risk-factor analysis. Eur Urol, 2013. 64: 486.
https://www.ncbi.nlm.nih.gov/pubmed/23490726
250.Sharma, P., et al. Sarcopenia as a predictor of complications in penile cancer patients undergoing inguinal lymph node dissection. World J Urol, 2015. 33: 1585.
https://www.ncbi.nlm.nih.gov/pubmed/25552207
251.Bevan-Thomas, R., et al. Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson Cancer Center Experience. J Urol, 2002. 167: 1638.
https://www.ncbi.nlm.nih.gov/pubmed/11912379
252.Bouchot, O., et al. Morbidity of inguinal lymphadenectomy for invasive penile carcinoma. Eur Urol, 2004. 45: 761.
https://www.ncbi.nlm.nih.gov/pubmed/15149749
253.Mistretta, F.A., et al. Adherence to guideline recommendations for lymph node dissection in squamous cell carcinoma of the penis: Effect on survival and complication rates. Urol Oncol, 2019. 37: 578 e11.
https://www.ncbi.nlm.nih.gov/pubmed/31296420
254.Nelson, B.A., et al. Complications of inguinal and pelvic lymphadenectomy for squamous cell carcinoma of the penis: a contemporary series. J Urol, 2004. 172: 494.
https://www.ncbi.nlm.nih.gov/pubmed/15247712
255.Ray, M.D., et al. Minimizing Post-operative Complications of Groin Dissection Using Modified Skin Bridge Technique: A Single-Centre Descriptive Study Showing Post-operative and Early Oncological Outcomes. World J Surg, 2018. 42: 3196.
https://www.ncbi.nlm.nih.gov/pubmed/29654358
256.Sotelo, R., et al. Complications and adverse events in lymphadenectomy of the inguinal area: worldwide expert consensus. BJS Open, 2024. 8.
https://www.ncbi.nlm.nih.gov/pubmed/38987232
257.Bertheuil, N., et al. Inguinal lymphadenectomy for stage III melanoma: a comparative study of two surgical approaches at the onset of lymphoedema. Eur J Surg Oncol, 2015. 41: 215.
https://www.ncbi.nlm.nih.gov/pubmed/25524886
258.Abbas, S., et al. Systematic review and meta-analysis of the used surgical techniques to reduce leg lymphedema following radical inguinal nodes dissection. Surg Oncol, 2011. 20: 88.
https://www.ncbi.nlm.nih.gov/pubmed/20005090
259.Tonouchi, H., et al. Operative morbidity associated with groin dissections. Surg Today, 2004. 34: 413.
https://www.ncbi.nlm.nih.gov/pubmed/15108079
260.Schmid, S.C., et al. Final results of the PraVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure. World J Urol, 2021. 39: 613.
https://www.ncbi.nlm.nih.gov/pubmed/32372159
261.Tranoulis, A., et al. The Impact of Saphenous Vein Sparing During Inguinal Lymphadenectomy on Postoperative Morbidity in Women With Vulval Cancer: An Updated Per-Groin Meta-analysis of Short-term Outcomes. Int J Gynecol Cancer, 2018. 28: 1232.
https://www.ncbi.nlm.nih.gov/pubmed/29787421
262.Cui, Y., et al. Saphenous vein sparing during laparoscopic bilateral inguinal lymphadenectomy for penile carcinoma patients. Int Urol Nephrol, 2016. 48: 363.
https://www.ncbi.nlm.nih.gov/pubmed/26660956
263.Pouwer, A.W., et al. Volume-controlled versus short drainage after inguinofemoral lymphadenectomy in vulvar cancer patients: A Dutch nationwide prospective study. Gynecol Oncol, 2017. 146: 580.
https://www.ncbi.nlm.nih.gov/pubmed/28687171
264.Weldrick, C., et al. A comparison of fibrin sealant versus standard closure in the reduction of postoperative morbidity after groin dissection: A systematic review and meta-analysis. Eur J Surg Oncol, 2014. 40: 1391.
https://www.ncbi.nlm.nih.gov/pubmed/25125341
265.Matthey-Gie, M.L., et al. Prospective Randomized Study to Compare Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Therapeutic Lymph Node Dissection With or Without the Use of an Ultrasonic Scalpel. Ann Surg Oncol, 2016. 23: 1716.
https://www.ncbi.nlm.nih.gov/pubmed/26714939
266.Pouwer, A.W., et al. Reduced morbidity by using LigaSure compared to conventional inguinofemoral lymphadenectomy in vulvar cancer patients: A randomized controlled trial. Surg Oncol, 2020. 35: 149.
https://www.ncbi.nlm.nih.gov/pubmed/32877884
267.Schwentner, C., et al. Endoscopic inguinofemoral lymphadenectomy--extended follow-up. J Endourol, 2013. 27: 497.
https://www.ncbi.nlm.nih.gov/pubmed/23067251
268.Kumar, V., et al. Prospective study comparing video-endoscopic radical inguinal lymph node dissection (VEILND) with open radical ILND (OILND) for penile cancer over an 8-year period. BJU Int, 2017. 119: 530.
https://www.ncbi.nlm.nih.gov/pubmed/27628265
269.Singh, A., et al. Comparing Outcomes of Robotic and Open Inguinal Lymph Node Dissection in Patients with Carcinoma of the Penis. J Urol, 2018. 199: 1518.
https://www.ncbi.nlm.nih.gov/pubmed/29307685
270.Mosti, G., et al. Compression therapy in lymphedema: Between past and recent scientific data. Phlebology, 2019. 34: 515.
https://www.ncbi.nlm.nih.gov/pubmed/30626269
271.Ettema, H.B., et al. Prevention of venous thromboembolism in patients with immobilization of the lower extremities: a meta-analysis of randomized controlled trials. J Thromb Haemost, 2008. 6: 1093.
https://www.ncbi.nlm.nih.gov/pubmed/18429944
272.Lightner, D.J., et al. Best Practice Statement on Urologic Procedures and Antimicrobial Prophylaxis. J Urol, 2020. 203: 351.
https://www.ncbi.nlm.nih.gov/pubmed/31441676
273.Jindal, T., et al. Laparoscopic and robotic video endoscopic inguinal lymphadenectomy by the lateral approach. Asian J Endosc Surg, 2021. 14: 464.
https://www.ncbi.nlm.nih.gov/pubmed/33200462
274.Yuan, P., et al. Comparative Study of Video Endoscopic Inguinal Lymphadenectomy Through a Hypogastric vs Leg Subcutaneous Approach for Penile Cancer. J Endourol, 2018. 32: 66.
https://www.ncbi.nlm.nih.gov/pubmed/29256632
275.Subira-Rios, D., et al. Minimally Invasive Laparoscopic Technique for Lymph Node Dissection in Penile Cancer: The Pelvic and Inguinal Single-Site Approach: PISA Technique. Urology, 2021. 153: 351.
https://www.ncbi.nlm.nih.gov/pubmed/33915082
276.Postlewait, L.M., et al. A Minimally Invasive Approach for Inguinal Lymphadenectomy in Melanoma and Genitourinary Malignancy: Long-Term Outcomes in an Attempted Randomized Control Trial. Ann Surg Oncol, 2017. 24: 3237.
https://www.ncbi.nlm.nih.gov/pubmed/28770482
277.Fankhauser, C.D., et al. Saphenous-sparing Ascending Video Endoscopic Inguinal Lymph Node Dissection Using a Leg Approach: Surgical Technique and Perioperative and Pathological Outcomes. Eur Urol Open Sci, 2022. 35: 9.
https://www.ncbi.nlm.nih.gov/pubmed/34825230
278.Wang, S., et al. Comparison of Efficiency of Video Endoscopy and Open Inguinal Lymph Node Dissection. Anticancer Res, 2017. 37: 4623.
https://www.ncbi.nlm.nih.gov/pubmed/28739762
279.Shao, Y., et al. Comparison of different surgical methods and strategies for inguinal lymph node dissection in patients with penile cancer. Sci Rep, 2022. 12: 2560.
https://www.ncbi.nlm.nih.gov/pubmed/35169241
280.Tan, Y.G., et al. Comparing the Perioperative and Oncological Outcomes of Open Versus Minimally Invasive Inguinal Lymphadenectomy in Penile Cancer: A Systematic Review and Meta-Analysis. Cancers (Basel), 2025. 17.
https://www.ncbi.nlm.nih.gov/pubmed/41008879
281.Tang, S., et al. A study protocol for a feasibility randomised controlled trial investigating videoendoscopic radical inguinal lymphadenectomy versus open radical inguinal lymphadenectomy in patients with penile cancer (VELRAD). Pilot Feasibility Stud, 2024. 10: 61.
https://www.ncbi.nlm.nih.gov/pubmed/38600541
282.Lont, A.P., et al. Pelvic lymph node dissection for penile carcinoma: extent of inguinal lymph node involvement as an indicator for pelvic lymph node involvement and survival. J Urol, 2007. 177: 947.
https://www.ncbi.nlm.nih.gov/pubmed/17296384
283.Liu, J.Y., et al. The risk factors for the presence of pelvic lymph node metastasis in penile squamous cell carcinoma patients with inguinal lymph node dissection. World J Urol, 2013. 31: 1519.
https://www.ncbi.nlm.nih.gov/pubmed/23455885
284.Djajadiningrat, R.S., et al. Prophylactic pelvic lymph node dissection in patients with penile cancer. J Urol, 2015. 193: 1976.
https://www.ncbi.nlm.nih.gov/pubmed/25498573
285.Lughezzani, G., et al. The relationship between characteristics of inguinal lymph nodes and pelvic lymph node involvement in penile squamous cell carcinoma: a single institution experience. J Urol, 2014. 191: 977.
https://www.ncbi.nlm.nih.gov/pubmed/24262497
286.Zhu, Y., et al. Prospectively packaged ilioinguinal lymphadenectomy for penile cancer: the disseminative pattern of lymph node metastasis. J Urol, 2009. 181: 2103.
https://www.ncbi.nlm.nih.gov/pubmed/19286211
287.Li, Z.S., et al. Bilateral pelvic lymph node dissection for Chinese patients with penile cancer: a multicenter collaboration study. J Cancer Res Clin Oncol, 2017. 143: 329.
https://www.ncbi.nlm.nih.gov/pubmed/27771796
288.Ottenhof, S.R., et al. F-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography Has High Diagnostic Value for Pelvic and Distant Staging in Patients with High-risk Penile Carcinoma. Eur Urol Focus, 2022. 8: 98.
https://www.ncbi.nlm.nih.gov/pubmed/33685842
289.Ashwin Sachdeva, et al. Management of Lymph Node-positive Penile Cancer: A Systematic Review. Eur Urol, 2023. 85: 257.
https://pubmed.ncbi.nlm.nih.gov/37208237/
290.Ravi, R., et al. Role of radiation therapy in the treatment of carcinoma of the penis. Br J Urol, 1994. 74: 646.
https://www.ncbi.nlm.nih.gov/pubmed/7530129
291.Alnajjar, H.M., et al. Long-term outcomes for penile cancer patients presenting with advanced N3 disease requiring a myocutaneous flap reconstruction or primary closure-a retrospective single centre study. Transl Androl Urol, 2019. 8: S13.
https://www.ncbi.nlm.nih.gov/pubmed/31143667
292.Koifman, L., et al. The role of primary inguinal surgical debulking for locally advanced penile cancer followed by reconstruction with myocutaneous flap. Int Braz J Urol, 2021. 47: 1162.
https://www.ncbi.nlm.nih.gov/pubmed/34115458
293.Canter, D.J., et al. The International Penile Advanced Cancer Trial (InPACT): Rationale and Current Status. Eur Urol Focus, 2019. 5: 706.
https://www.ncbi.nlm.nih.gov/pubmed/31160252
294.Hussein, A.M., et al. Chemotherapy with cisplatin and 5-fluorouracil for penile and urethral squamous cell carcinomas. Cancer, 1990. 65: 433.
https://www.ncbi.nlm.nih.gov/pubmed/2297633
295.Shammas, F.V., et al. Cisplatin and 5-fluorouracil in advanced cancer of the penis. J Urol, 1992. 147: 630.
https://www.ncbi.nlm.nih.gov/pubmed/1538445
296.Leijte, J.A., et al. Neoadjuvant chemotherapy in advanced penile carcinoma. Eur Urol, 2007. 52: 488.
https://www.ncbi.nlm.nih.gov/pubmed/17316964
297.Sharma, P., et al. Adjuvant chemotherapy is associated with improved overall survival in pelvic node-positive penile cancer after lymph node dissection: a multi-institutional study. Urol Oncol, 2015. 33: 496 e17.
https://www.ncbi.nlm.nih.gov/pubmed/26072110
298.Necchi, A., et al. Prognostic Factors of Adjuvant Taxane, Cisplatin, and 5-Fluorouracil Chemotherapy for Patients With Penile Squamous Cell Carcinoma After Regional Lymphadenectomy. Clin Genitourin Cancer, 2016. 14: 518.
https://www.ncbi.nlm.nih.gov/pubmed/27050716
299.Dhasthakeer, U., et al. Comparison of efficacy and toxicity of chemotherapeutic regimens used as adjuvant and/or neoadjuvant chemotherapy in penile cancer patients. Curr Probl Cancer, 2025. 55: 101185.
https://www.ncbi.nlm.nih.gov/pubmed/39893772
300.An, X., et al. Neoadjuvant toripalimab plus nimotuzumab combined with taxol-based chemotherapy in locally advanced penile squamous cell carcinoma. Cancer Cell, 2025. 43: 970.
https://www.ncbi.nlm.nih.gov/pubmed/40215977
301.Necchi, A., et al. Nomogram-based prediction of overall survival after regional lymph node dissection and the role of perioperative chemotherapy in penile squamous cell carcinoma: A retrospective multicenter study. Urol Oncol, 2019. 37: 531 e7.
https://www.ncbi.nlm.nih.gov/pubmed/31053524
302.Raup, V., et al. Mp49-091397058899Adjuvant Chemotherapy in the Treatment of Lymph Node Positive Squamous Cell Carcinoma of the Penis: Analysis of the National Cancer Data Base. Journal of Urology, 2019. 201: e709.
https://www.auajournals.org/doi/abs/10.1097/01.JU.0000556432.48421.1e
303.Paz Rojas, J.F., et al. Effectiveness and safety of adjuvant chemotherapy compared to neoadjuvant chemotherapy in patients with penile cancer and positive lymph nodes regarding overall survival and free disease survival: a systematic review and meta-analysis. Urol Oncol, 2022. 40: 200 e11.
https://www.ncbi.nlm.nih.gov/pubmed/35307290
304.Patel, A., et al. Updates in the use of radiotherapy in the management of primary and locally-advanced penile cancer. Asian J Urol, 2022. 9: 389.
https://www.ncbi.nlm.nih.gov/pubmed/36381600
305.Hakenberg, O.W., et al. EAU guidelines on penile cancer: 2014 update. Eur Urol, 2015. 67: 142.
https://www.ncbi.nlm.nih.gov/pubmed/25457021
306.Robinson, R., et al. Risks and Benefits of Adjuvant Radiotherapy After Inguinal Lymphadenectomy in Node-positive Penile Cancer: A Systematic Review by the European Association of Urology Penile Cancer Guidelines Panel. Eur Urol, 2018. 74: 76.
https://www.ncbi.nlm.nih.gov/pubmed/29703686
307.Chen, M.F., et al. Contemporary management of penile cancer including surgery and adjuvant radiotherapy: an experience in Taiwan. World J Urol, 2004. 22: 60.
https://www.ncbi.nlm.nih.gov/pubmed/14657999
308.Yuan, Z., et al. The relationship between HPV status and chemoradiotherapy in the locoregional control of penile cancer. World J Urol, 2018. 36: 1431.
https://www.ncbi.nlm.nih.gov/pubmed/29589134
309.Jaipuria, J., et al. Adjuvant radiation compares favorably to chemotherapy in patients with carcinoma penis and nodal positivity restricted to groin. Urol Oncol, 2020. 38: 641 e9.
https://www.ncbi.nlm.nih.gov/pubmed/32334927
310.Johnstone, P.A.S., et al. Primary Penile Cancer: The Role of Adjuvant Radiation Therapy in the Management of Extranodal Extension in Lymph Nodes. Eur Urol Focus, 2019. 5: 737.
https://www.ncbi.nlm.nih.gov/pubmed/30327282
311.Ager, M., et al. Long-term multicentre experience of adjuvant radiotherapy for pN3 squamous cell carcinoma of the penis. BJU Int, 2021. 128: 451.
https://www.ncbi.nlm.nih.gov/pubmed/33249744
312.Tang, D.H., et al. Adjuvant pelvic radiation is associated with improved survival and decreased disease recurrence in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study. Urol Oncol, 2017. 35: 605 e17.
https://www.ncbi.nlm.nih.gov/pubmed/28666722
313.Yuan, Z., et al. Intrinsic radiosensitivity, genomic-based radiation dose and patterns of failure of penile cancer in response to adjuvant radiation therapy. Rep Pract Oncol Radiother, 2019. 24: 593.
https://www.ncbi.nlm.nih.gov/pubmed/31719799
314.Yuan, Z., et al. Radiation therapy in the management of the inguinal region in penile cancer: What’s the evidence? Urol Oncol, 2022. 40: 223.
https://www.ncbi.nlm.nih.gov/pubmed/32482510
315.Winters, B.R., et al. Is there a benefit to adjuvant radiation in stage III penile cancer after lymph node dissection? Findings from the National Cancer Database. Urol Oncol, 2018. 36: 92 e11.
https://www.ncbi.nlm.nih.gov/pubmed/29174944
316.Choo, R., et al. Is there any benefit in adding postoperative adjuvant concurrent radiotherapy and chemotherapy for penile cancer with regional lymph node metastasis? Minerva Urol Nefrol, 2020. 72: 474.
https://www.ncbi.nlm.nih.gov/pubmed/31353875
317.Maibom, S.L., et al. DaPeCa-4: outcome in penile cancer patients with N3 disease due to extra nodal extension treated with surgery and chemo-irradiation. Scand J Urol, 2020. 54: 334.
https://www.ncbi.nlm.nih.gov/pubmed/32734838
318.Haas, G.P., et al. Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol, 1999. 161: 1823.
https://www.ncbi.nlm.nih.gov/pubmed/10332445
319.Di Lorenzo, G., et al. Cisplatin and 5-fluorouracil in inoperable, stage IV squamous cell carcinoma of the penis. BJU Int, 2012. 110: E661.
https://www.ncbi.nlm.nih.gov/pubmed/22958571
320.Zhang, S., et al. Phase II study of docetaxel, cisplatin, and fluorouracil in patients with distantly metastatic penile cancer as first-line chemotherapy. Oncotarget, 2015. 6: 32212.
https://www.ncbi.nlm.nih.gov/pubmed/26311739
321.Di Lorenzo, G., et al. Paclitaxel in pretreated metastatic penile cancer: final results of a phase 2 study. Eur Urol, 2011. 60: 1280.
https://www.ncbi.nlm.nih.gov/pubmed/21871710
322.Liu, W.K., et al. Longitudinal cohort analysis of patients with metastatic penile cancer treated in a large quaternary academic centre. Journal of Clinical Urology, 2021. 16: 293.
https://journals.sagepub.com/doi/abs/10.1177/20514158211025913
323.Wang, J., et al. Treatment for Metastatic Penile Cancer After First-line Chemotherapy Failure: Analysis of Response and Survival Outcomes. Urology, 2015. 85: 1104.
https://www.ncbi.nlm.nih.gov/pubmed/25819619
324.Noronha, V., et al. Role of paclitaxel and platinum-based adjuvant chemotherapy in high-risk penile cancer. Urol Ann, 2012. 4: 150.
https://www.ncbi.nlm.nih.gov/pubmed/23248520
325.Bermejo, C., et al. Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol, 2007. 177: 1335.
https://www.ncbi.nlm.nih.gov/pubmed/17382727
326.Joshi, V.B., et al. Immune-based therapies in penile cancer. Nat Rev Urol, 2022. 19: 457.
https://www.ncbi.nlm.nih.gov/pubmed/35851333
327.El Zarif, T., et al. Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors. J Natl Cancer Inst, 2023. 115: 1605.
https://www.ncbi.nlm.nih.gov/pubmed/37563779
328.Xiong, L., et al. First-Line PD-1 Blockade Combined With Chemotherapy for Stage IV Penile Squamous Cell Carcinoma: A Multicenter Retrospective Study. J Natl Compr Canc Netw, 2024. 23.
https://www.ncbi.nlm.nih.gov/pubmed/39705804
329.Yan, R., et al. First-line programmed death receptor-1 (PD-1) inhibitor and epidermal growth factor receptor (EGFR) blockade, combined with platinum-based chemotherapy, for stage IV penile cancer. BJU Int, 2023. 131: 198.
https://www.ncbi.nlm.nih.gov/pubmed/35704436
330.Zhuang, T.Z., et al. Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience. J Immunother Precis Oncol, 2025. 8: 1.
https://www.ncbi.nlm.nih.gov/pubmed/39811423
331.Rouvinov, K., et al. Cemiplimab as First Line Therapy in Advanced Penile Squamous Cell Carcinoma: A Real-World Experience. J Pers Med, 2023. 13.
https://www.ncbi.nlm.nih.gov/pubmed/38003938
332.Apolo, A.B., et al. Final Results From a Phase I Trial and Expansion Cohorts of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced/Metastatic Genitourinary Tumors. J Clin Oncol, 2024. 42: 3033.
https://www.ncbi.nlm.nih.gov/pubmed/38954785
333.McGregor, B.A., et al. Results of a multicenter, phase 2 study of nivolumab and ipilimumab for patients with advanced rare genitourinary malignancies. Cancer, 2021. 127: 840.
https://www.ncbi.nlm.nih.gov/pubmed/33216356
334.de Vries, H.M., et al. Atezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial. J Clin Oncol, 2023. 41: 4872.
https://www.ncbi.nlm.nih.gov/pubmed/37487169
335.Garcia Del Muro, X., et al. Retifanlimab in Advanced Penile Squamous Cell Carcinoma: The Phase 2 ORPHEUS Study. Eur Urol Oncol, 2025. 8: 278.
https://www.ncbi.nlm.nih.gov/pubmed/38749903
336.Cotait Maluf, F., et al. Pembrolizumab Plus Platinum-Based Chemotherapy for Patients With Advanced Penile Cancer: The Nonrandomized HERCULES (LACOG 0218) Clinical Trial. JAMA Oncol, 2025. 11: 1314.
https://www.ncbi.nlm.nih.gov/pubmed/40965911
337.Brown, A., et al. Epidermal growth factor receptor-targeted therapy in squamous cell carcinoma of the penis: a report of 3 cases. Urology, 2014. 83: 159.
https://www.ncbi.nlm.nih.gov/pubmed/24238569
338.Carthon, B.C., et al. Epidermal growth factor receptor-targeted therapy in locally advanced or metastatic squamous cell carcinoma of the penis. BJU Int, 2014. 113: 871.
https://www.ncbi.nlm.nih.gov/pubmed/24053151
339.Necchi, A., et al. Proof of activity of anti-epidermal growth factor receptor-targeted therapy for relapsed squamous cell carcinoma of the penis. J Clin Oncol, 2011. 29: e650.
https://www.ncbi.nlm.nih.gov/pubmed/21632506
340.Necchi, A., et al. First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study. BJU Int, 2018. 121: 348.
https://www.ncbi.nlm.nih.gov/pubmed/28921872
341.Necchi, A., et al. Advanced Squamous Cell Carcinomas of the Pelvic and Perineal Region: A Comprehensive Genomic Profiling Study. Oncologist, 2022. 27: 1016.
https://www.ncbi.nlm.nih.gov/pubmed/35881043
342.Lutz, S.T., et al. Role of radiation therapy in palliative care of the patient with cancer. J Clin Oncol, 2014. 32: 2913.
https://www.ncbi.nlm.nih.gov/pubmed/25113773
343.Brennan, J. Adjustment to cancer - coping or personal transition? Psychooncology, 2001. 10: 1.
https://www.ncbi.nlm.nih.gov/pubmed/11180573
344.Horenblas, S., et al. Local recurrent tumour after penis-conserving therapy. A plea for long-term follow-up. Br J Urol, 1993. 72: 976.
https://www.ncbi.nlm.nih.gov/pubmed/8306171
345.Branney, P., et al. The feasibility of patient reported outcome measures for the care of penile cancer. International Journal of Urological Nursing, 2021. 16: 138.
https://onlinelibrary.wiley.com/doi/abs/10.1111/ijun.12307
346.Adegboye, O., et al. The Development and Feasibility of a Novel Electronic Patient-Reported Outcome Measures (Eproms) Questionnaire in patients with penile cancer. Clin Genitourin Cancer, 2024. 22: 102168.
https://www.ncbi.nlm.nih.gov/pubmed/39117530
347.Ager, M., et al. Mp49-151397058899Surveillance Ct Algorithm for Node Positive Squamous Cell Carcinoma of the Penis. Journal of Urology, 2019. 201: e711.
https://www.auajournals.org/doi/abs/10.1097/01.JU.0000556430.71291.09
348.Arora, A., et al. Patterns of recurrence in penile cancer: Implications for surveillance strategies. European Urology, 2022. 81: S1033.
https://www.sciencedirect.com/science/article/pii/S0302283822007746
349.Chakiryan, N.H., et al. Patterns of Recurrence following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies. J Urol, 2021. 206: 960.
https://www.ncbi.nlm.nih.gov/pubmed/34032492
350.Vreeburg, M.T.A., et al. Evaluating follow-up in patients with lymph node-negative penile cancer at a high-volume centre. BJU Int, 2025. 136: 675.
https://www.ncbi.nlm.nih.gov/pubmed/40551380
351.Fazili, A., et al. Early postoperative visits improve outcomes in inguinal lymph node dissection for penile cancer. BJU Int, 2025. 136: 289.
https://www.ncbi.nlm.nih.gov/pubmed/40318206
352.Pang, K.H., et al. Outcomes of penile sarcomatoid squamous cell carcinoma from a single tertiary referral centre: a matched cohort study. BJU Int, 2023. 132: 337.
https://www.ncbi.nlm.nih.gov/pubmed/37169730
353.Parnham, A.S., et al. Glansectomy and Split-thickness Skin Graft for Penile Cancer. Eur Urol, 2018. 73: 284.
https://www.ncbi.nlm.nih.gov/pubmed/27746062
354.Djajadiningrat, R.S., et al. Ultrasound examination and fine needle aspiration cytology-useful for followup of the regional nodes in penile cancer? J Urol, 2014. 191: 652.
https://www.ncbi.nlm.nih.gov/pubmed/23994372
355.Branney, P., et al. Mortality and sexuality after diagnosis of penile cancer: a participative study. International Journal of Urological Nursing, 2015. 10: 137.
https://onlinelibrary.wiley.com/doi/abs/10.1111/ijun.12106
356.Ayres, B.E. Psychosocial Impact of Penile Cancer: An Unmet Need. Urol Clin North Am, 2024. 51: 327.
https://www.ncbi.nlm.nih.gov/pubmed/38925735
357.Simpson, W.G., et al. Analysis of Suicide Risk in Patients with Penile Cancer and Review of the Literature. Clin Genitourin Cancer, 2018. 16: e257.
https://www.ncbi.nlm.nih.gov/pubmed/29126815
358.Keeley, V., et al. A quality of life measure for limb lymphoedema (LYMQOL) J. Lymphoedema,
2010. 5: 26.
https://eprovide.mapi-trust.org/instruments/lymqol
359.Rosen, R.C., et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology, 1997. 49: 822.
https://www.ncbi.nlm.nih.gov/pubmed/9187685
360.Ware, J.E., et al., Conceptualization and Measurement of Health for Adults in the Health Insurance Study: Vol. I, Model of Health and Methodology. 1980, Santa Monica, CA.
https://www.rand.org/pubs/reports/R1987z1.html
361.European Organisation for Research and Treatment of Cancer (EORTC). EORTC QLQ-C30 (version 3). 2018. 2022.
https://www.eortc.org/app/uploads/sites/2/2018/08/Specimen-QLQ-C30-English.pdf
362.Draeger, D.L., et al. Cross-Sectional Patient-Reported Outcome Measuring of Health-Related Quality of Life With Establishment of Cancer- and Treatment-Specific Functional and Symptom Scales in Patients With Penile Cancer. Clin Genitourin Cancer, 2018. 16: e1215.
https://www.ncbi.nlm.nih.gov/pubmed/30201215
363.Zigmond, A.S., et al. The hospital anxiety and depression scale. Acta Psychiatr Scand, 1983. 67: 361.
https://www.ncbi.nlm.nih.gov/pubmed/6880820
364.Bigelow, D.A., et al. Quality of life of community mental health program clients: validating a measure. Community Ment Health J, 1991. 27: 43.
https://www.ncbi.nlm.nih.gov/pubmed/2019098
365.Herbenick, D., et al. The development and validation of the Male Genital Self-Image Scale: results from a nationally representative probability sample of men in the United States. J Sex Med, 2013. 10: 1516.
https://www.ncbi.nlm.nih.gov/pubmed/23551571
366.Romero, F.R., et al. Sexual function after partial penectomy for penile cancer. Urology, 2005. 66: 1292.
https://www.ncbi.nlm.nih.gov/pubmed/16360459
367.D’Ancona, C.A., et al. Quality of life after partial penectomy for penile carcinoma. Urology, 1997. 50: 593.
https://www.ncbi.nlm.nih.gov/pubmed/9338738
368.Kieffer, J.M., et al. Quality of life for patients treated for penile cancer. J Urol, 2014. 192: 1105.
https://www.ncbi.nlm.nih.gov/pubmed/24747092
369.Ficarra, V., et al. General state of health and psychological well-being in patients after surgery for urological malignant neoplasms. Urol Int, 2000. 65: 130.
https://www.ncbi.nlm.nih.gov/pubmed/11054029
370.Sosnowski, R., et al. Assessment of quality of life in patients surgically treated for penile cancer: Impact of aggressiveness in surgery. Eur J Oncol Nurs, 2017. 31: 1.
https://www.ncbi.nlm.nih.gov/pubmed/29173821
371.Wan, X., et al. A Comparative study of two types of organ-sparing surgeries for early stage penile cancer: Wide local excision vs partial penectomy. Eur J Surg Oncol, 2018. 44: 1425.
https://www.ncbi.nlm.nih.gov/pubmed/29656798
372.Skeppner, E., et al. Treatment-seeking, aspects of sexual activity and life satisfaction in men with laser-treated penile carcinoma. Eur Urol, 2008. 54: 631.
https://www.ncbi.nlm.nih.gov/pubmed/18788122
373.Croghan, S.M., et al. Phallus Preservation in Penile Cancer Surgery: Patient-reported Aesthetic & Functional Outcomes. Urology, 2021. 152: 60.
https://www.ncbi.nlm.nih.gov/pubmed/33600836
374.Opjordsmoen, S., et al. Quality of life in patients treated for penile cancer. A follow-up study. Br J Urol, 1994. 74: 652.
https://www.ncbi.nlm.nih.gov/pubmed/7827818
375.Gulino, G., et al. Sexual outcomes after organ potency-sparing surgery and glans reconstruction in patients with penile carcinoma. Indian J Urol, 2013. 29: 119.
https://www.ncbi.nlm.nih.gov/pubmed/23956513
376.Carver, B.S., et al. Squamous cell carcinoma of the penis: a retrospective review of forty-five patients in northwest Louisiana. South Med J, 2002. 95: 822.
https://www.ncbi.nlm.nih.gov/pubmed/12190215
377.Lukowiak, T.M., et al. Mohs micrographic surgery for male genital tumors: Local recurrence rates and patient-reported outcomes. J Am Acad Dermatol, 2021. 84: 1030.
https://www.ncbi.nlm.nih.gov/pubmed/33279645
378.Sansalone, S., et al. Sexual outcomes after partial penectomy for penile cancer: results from a multi-institutional study. Asian J Androl, 2017. 19: 57.
https://www.ncbi.nlm.nih.gov/pubmed/26643562
379.Sosnowski, R., et al. Assessment of selected quality of life domains in patients who have undergone conservative or radical surgical treatment for penile cancer: an observational study. Sex Health, 2019. 16: 32.
https://www.ncbi.nlm.nih.gov/pubmed/30532994
380.Sedigh, O., et al. Sexual function after surgical treatment for penile cancer: Which organ-sparing approach gives the best results? Can Urol Assoc J, 2015. 9: E423.
https://www.ncbi.nlm.nih.gov/pubmed/26279710
381.Yang, J., et al. Glans-reconstruction with preputial flap is superior to primary closure for post-surgical restoration of male sexual function in glans-preserving surgery. Andrology, 2014. 2: 729.
https://www.ncbi.nlm.nih.gov/pubmed/24923484
382.Morelli, G., et al. Glansectomy with split-thickness skin graft for the treatment of penile carcinoma. Int J Impot Res, 2009. 21: 311.
https://www.ncbi.nlm.nih.gov/pubmed/19458620
383.O’Kane, H.F., et al. Outcome of glansectomy and skin grafting in the management of penile cancer. Adv Urol, 2011. 2011: 240824.
https://www.ncbi.nlm.nih.gov/pubmed/21603193
384.Palminteri, E., et al. Aesthetic neo-glans reconstruction after penis-sparing surgery for benign, premalignant or malignant penile lesions. Arab J Urol, 2011. 9: 115.
https://www.ncbi.nlm.nih.gov/pubmed/26579279
385.Li, J., et al. Organ-sparing surgery for penile cancer: complications and outcomes. Urology, 2011. 78: 1121.
https://www.ncbi.nlm.nih.gov/pubmed/22054385
386.Preto, M., et al. Functional and Patient Reported Outcomes Following Total Glans Resurfacing. J Sex Med, 2021. 18: 1099.
https://www.ncbi.nlm.nih.gov/pubmed/33935017
387.Monteiro, L.L., et al. Erectile function after partial penectomy for penile cancer. Int Braz J Urol, 2021. 47: 515.
https://www.ncbi.nlm.nih.gov/pubmed/33620995
388.Crook, J.M., et al. Penile brachytherapy: results for 49 patients. Int J Radiat Oncol Biol Phys, 2005. 62: 460.
https://www.ncbi.nlm.nih.gov/pubmed/15890588
389.Makarewicz, R., et al. Interstitial brachytherapy for penile cancer: the experience of Oncology Centre in Bydgoszcz. J Contemp Brachytherapy, 2010. 2: 157.
https://www.ncbi.nlm.nih.gov/pubmed/27853477
390.Windahl, T., et al. Sexual function and satisfaction in men after laser treatment for penile carcinoma. J Urol, 2004. 172: 648.
https://www.ncbi.nlm.nih.gov/pubmed/15247753
391.White, E., et al. Impact of lymphoedema on quality of life following radical lymph node dissection for penile cancer. Int J Surg, 2016. 36: 38.
https://www.sciencedirect.com/science/article/pii/S1743919116303600?via%3Dihub
392.Correa, A.F., et al. Differences in Survival Associated with Performance of Lymph Node Dissection in Patients with Invasive Penile Cancer: Results from the National Cancer Database. J Urol, 2018. 199: 1238.
https://www.ncbi.nlm.nih.gov/pubmed/29248557
393.The British Lymphology Society and the Lymphoedema Support Network. Guidelines on the Management of Cellulitis in Lymphoedema 2022.
https://www.lymphoedema.org/wp-content/uploads/2025/09/management_cellulitis.pdf
394.Scaglioni, M.F., et al. Systematic review of lymphovenous anastomosis (LVA) for the treatment of lymphedema. Microsurgery, 2017. 37: 947.
https://www.ncbi.nlm.nih.gov/pubmed/28972280
395.Jakobsen, J.K., et al. Centralization and Equitable Care in Rare Urogenital Malignancies: The Case for Penile Cancer. Eur Urol Focus, 2021. 7: 924.
https://www.ncbi.nlm.nih.gov/pubmed/34593356
396.Chipollini, J., et al. National Trends and Predictors of Organ-sparing for Invasive Penile Tumors: Expanding the Therapeutic Window. Clin Genitourin Cancer, 2018. 16: e383.
https://www.ncbi.nlm.nih.gov/pubmed/28967504
397.Jakobsen, J.K., et al. DaPeCa-2: Implementation of fast-track clinical pathways for penile cancer shortens waiting time and accelerates the diagnostic process--A comparative before-and-after study in a tertiary referral centre in Denmark. Scand J Urol, 2016. 50: 80.
https://www.ncbi.nlm.nih.gov/pubmed/26271679
398.Kirrander, P., et al. Swedish National Penile Cancer Register: incidence, tumour characteristics, management and survival. BJU Int, 2016. 117: 287.
https://www.ncbi.nlm.nih.gov/pubmed/25395083
399.Zhu, Y., et al. Important Therapeutic Considerations in T1b Penile Cancer: Prognostic Significance and Adherence to Treatment Guidelines. Ann Surg Oncol, 2019. 26: 685.
https://www.ncbi.nlm.nih.gov/pubmed/30565040
400.Bada, M., et al. Adherence to the EAU guidelines on Penile Cancer Treatment: European, multicentre, retrospective study. J Cancer Res Clin Oncol, 2019. 145: 921.
https://www.ncbi.nlm.nih.gov/pubmed/30825028
401.Pecoraro, A., et al. Impact of the Standardization of Penile Cancer Care on the Quality of Care, Outcomes, and Academic-driven Centralization in a Single eUROGEN Referral Center. Eur Urol Focus, 2024. 10: 57.
https://www.ncbi.nlm.nih.gov/pubmed/37537111
402.Thuret, R., et al. A contemporary population-based assessment of the rate of lymph node dissection for penile carcinoma. Ann Surg Oncol, 2011. 18: 439.
https://www.ncbi.nlm.nih.gov/pubmed/20839061
403.Anderson, S., et al. Penile cancer in Ireland - A national review. Surgeon, 2022. 20: 187.
https://www.ncbi.nlm.nih.gov/pubmed/34034967
404.Mistretta, F.A., et al. Adherence to Guideline Recommendations for Perioperative Chemotherapy in Patients with pN2-3 M0 Squamous Cell Carcinoma of the Penis: Temporal Trends and Survival Outcomes. Clin Oncol (R Coll Radiol), 2020. 32: e93.
https://www.ncbi.nlm.nih.gov/pubmed/31706712
405.Ulvskog, E., et al. Nationwide Data Support Centralised Decision-making in Penile Cancer Care: A Before-and-After Study on Guideline Adherence and Disease-specific survival for Patients with an Indication for Perioperative Oncological Treatment. Eur Urol Open Sci, 2023. 51: 70.
https://www.ncbi.nlm.nih.gov/pubmed/37187721
406.Ayres, B.E., et al. 50 Has centralisation of penile cancer services in the United Kingdom improved survival? European Urology Supplements, 2014. 13: e50.
https://www.sciencedirect.com/science/article/pii/S156990561460052X